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Vascular invasion in uterine sarcomas and its significance. A multi-institutional study.
Roma, Andres A; Barbuto, Denise A; Samimi, Siavash Azadmanesh; Stolnicu, Simona; Alvarado-Cabrero, Isabel; Chanona-Vilchis, Jose; Aguilera-Barrantes, Irene; de Peralta-Venturina, Mariza; Malpica, Anais; Rutgers, Joanne K L; Silva, Elvio G.
Afiliación
  • Roma AA; Department of Pathology and Laboratory Medicine, Cleveland Clinic, Cleveland, OH 44195. Electronic address: romaa@ccf.org.
  • Barbuto DA; Cedars-Sinai Medical Center, Los Angeles, CA, 90048.
  • Samimi SA; Cedars-Sinai Medical Center, Los Angeles, CA, 90048.
  • Stolnicu S; Targu Mures University of Medicine and Pharmacy, Targu Mures, 540139, Romania.
  • Alvarado-Cabrero I; Mexican Oncology Hospital, Mexico City, DF 06720, Mexico.
  • Chanona-Vilchis J; Instituto Nacional de Cancerologia (Mexico), Mexico City DF 14080, Mexico.
  • Aguilera-Barrantes I; Medical College of Wisconsin, Milwaukee, 53226, WI.
  • de Peralta-Venturina M; Cedars-Sinai Medical Center, Los Angeles, CA, 90048.
  • Malpica A; The University of Texas MD Anderson Cancer Center, Houston, 77030, TX.
  • Rutgers JK; Cedars-Sinai Medical Center, Los Angeles, CA, 90048.
  • Silva EG; Cedars-Sinai Medical Center, Los Angeles, CA, 90048; The University of Texas MD Anderson Cancer Center, Houston, 77030, TX.
Hum Pathol ; 46(11): 1712-21, 2015 Nov.
Article en En | MEDLINE | ID: mdl-26410057
Although metastases and high-mortality are frequent in high-grade endometrial sarcomas (HGSs), these findings are less commonly seen in low-grade endometrial stromal sarcomas (LGESSs), even in cases with lymphovascular invasion (LVI). We hypothesized that the "bulging plugs" of tumor characteristic of LVI in LGESS are fundamentally different from LVI seen in HGS. We reviewed 70 uterine sarcomas: 42 HGSs (high-grade endometrial stromal sarcomas, undifferentiated uterine sarcoma, and leiomyosarcoma) and 28 LGESSs. All cases had LVI documented on the histologic slides. Immunostains for CD31, ERG, and D2-40 were performed. LGESS harbored cohesive intravascular tumor foci with direct communication from the main tumor and attached to the vessel wall. The intravascular foci included tumor cells and small arteriole-type vessels and were surrounded by a thin fibrous band. Vascular markers confirmed the LVI and highlighted positively stained endothelial cells separating intravascular tumor foci from the blood itself. In contrast, intravascular tumor foci in HGS were composed of discohesive cells clusters, lacking the features described in LGESS. Only 8 (30.8%) patients with LGESS had recurrence/metastases (6 with lung metastasis); only 1 patient died of disease. Thirty (77%) patients with HGS had recurrence/metastases, 27 (69%) patients had lung metastases, and 22 (56.4%) patients died of disease. We propose that in most LGESSs, LVI represents vascular intrusion; manipulation or trauma is potentially responsible for tumor cell detachment into the circulation increasing the chances of recurrence/metastases. Classic LVI features were identified in HGS. This important distinction may allow for better management of patients and avoid unnecessary treatment in LGESS, reducing morbidity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sarcoma / Neoplasias Uterinas / Neoplasias Endometriales / Neovascularización Patológica Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Hum Pathol Asunto de la revista: PATOLOGIA Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sarcoma / Neoplasias Uterinas / Neoplasias Endometriales / Neovascularización Patológica Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Middle aged Idioma: En Revista: Hum Pathol Asunto de la revista: PATOLOGIA Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos