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Microbial spoilage, instability risk of antacid suspension in the presence of commonly used preservative system.
Khan, Jamshaid Ali; Khan, Imran Ullah; Iqbal, Zafar; Nasir, Fazli; Muhammad, Salar; Hannan, Peer Abdul; Ullah, Irfan.
Afiliación
  • Khan JA; Department of Pharmacy, University of Peshawar, Peshawar, KPK, Pakistan.
  • Khan IU; Department of Pharmacy, University of Peshawar, Peshawar, KPK, Pakistan.
  • Nasir F; Department of Pharmacy, University of Peshawar, Peshawar, KPK, Pakistan.
  • Muhammad S; Department of pharmacy, Abdul Wali Khan University, Mardan, KPK, Pakistan.
  • Hannan PA; Department of pharmacy, Abdul Wali Khan University, Mardan, KPK, Pakistan.
  • Ullah I; Department of Pharmacy, University of Peshawar, Peshawar, KPK, Pakistan.
Pak J Pharm Sci ; 28(5): 1637-46, 2015 Sep.
Article en En | MEDLINE | ID: mdl-26408871
Manifestation of microbial spoilage of any product by bacteria and to assess the effectiveness of the anti-microbial preservatives (parabens) used for the prevention and stability purpose. The aim of the present work is to study the effectiveness of preservatives used in the antacid suspensions and to analyze the effect of microbial growth on the quality of respective antacid suspensions. Samples of various antacid suspensions were randomly collected from local market and Government hospital pharmacies. Three different antacid formulations were prepared in the laboratory. All the formulations were preliminarily evaluated on the basis of organoleptic characteristics, pH, viscosity and assay. Efficacy of the preservative system in suspension formulation was determined by inoculating the samples in its final container, with specific strains of bacteria i.e. Escherichia coli ATCC 8739, Pseudomonas aeruginosa ATCC 9027 and Staphylococcus aureus ATCC 6538, taking samples from the inoculated preparation at specified intervals of time i.e. 0 time, 07 days, 14 days and 28 days, growing it on nutrient agar medium and colony forming units (CFUs) were scored by plate count. At the same time the samples were also subjected to qualitative and quantitative testing. The decrease in CFU and alteration in assay, pH and viscosity was observed in all the formulations except formulation M2 and F3 that showed stability throughout the study period.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conservadores Farmacéuticos / Contaminación de Medicamentos / Antiácidos Tipo de estudio: Etiology_studies / Qualitative_research / Risk_factors_studies Idioma: En Revista: Pak J Pharm Sci Asunto de la revista: FARMACIA / FARMACOLOGIA / QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Pakistán
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conservadores Farmacéuticos / Contaminación de Medicamentos / Antiácidos Tipo de estudio: Etiology_studies / Qualitative_research / Risk_factors_studies Idioma: En Revista: Pak J Pharm Sci Asunto de la revista: FARMACIA / FARMACOLOGIA / QUIMICA Año: 2015 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Pakistán