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How I Diagnose Non-thalassemic Microcytic Anemias.
Bruno, Mariasole; De Falco, Luigia; Iolascon, Achille.
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  • Bruno M; Department of Molecular Medicine and Medical Biotechnology, University Federico II, Naples, Italy; CEINGE, Advanced Biotechnologies, Naples, Italy; Department of Medicine, Section of Internal Medicine, University of Verona, AOUI-Policlinico GB Rossi, 37134 Verona, Italy.
  • De Falco L; Department of Molecular Medicine and Medical Biotechnology, University Federico II, Naples, Italy; CEINGE, Advanced Biotechnologies, Naples, Italy.
  • Iolascon A; Department of Molecular Medicine and Medical Biotechnology, University Federico II, Naples, Italy; CEINGE, Advanced Biotechnologies, Naples, Italy. Electronic address: achille.iolascon@gmail.com.
Semin Hematol ; 52(4): 270-8, 2015 Oct.
Article en En | MEDLINE | ID: mdl-26404439
Microcytic anemia is the most common form of anemia, characterized by reduced hemoglobin (Hb) synthesis associated with decreased red blood cell volume (MCV). It is a very heterogeneous group of diseases that may be either acquired or inherited. Microcytic hypochromic anemia can result from defects in globin (hemoglobinopathies or thalassemias) or heme synthesis or in iron availability, or acquisition by the erythroid precursors. Diagnosis of microcytic anaemia appears to be important in children/adolescents, especially to set, where possible, a treatment plan on the basis of the etiology and pathogenesis. After excluding the acquired causes of microcytic anemia that represent the most frequent etiology, according to the differential diagnosis, the analysis of genetic causes, mostly hereditary, must be considered. This review will consider acquired and hereditary microcytic anemias due to heme synthesis or to iron metabolism defects and their diagnosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anemia Ferropénica / Anemia Hipocrómica Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: Semin Hematol Año: 2015 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Anemia Ferropénica / Anemia Hipocrómica Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: Semin Hematol Año: 2015 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos