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Antipsychotic use and unexpected death: a hospital-based case-control study.
Mace, S; Dzahini, O; Cornelius, V; Anthony, D; Stewart, R; Taylor, D.
Afiliación
  • Mace S; Pharmacy Department, South London and Maudsley NHS Foundation Trust, London, UK.
  • Dzahini O; Institute of Pharmaceutical Science, King's College London, London, UK.
  • Cornelius V; Pharmacy Department, South London and Maudsley NHS Foundation Trust, London, UK.
  • Anthony D; Institute of Pharmaceutical Science, King's College London, London, UK.
  • Stewart R; Department of Primary Care & Public Health Sciences, School of Medicine, King's College London, London, UK.
  • Taylor D; Department of Medicine, Imperial College London, London, UK.
Acta Psychiatr Scand ; 132(6): 479-88, 2015 Dec.
Article en En | MEDLINE | ID: mdl-26403992
OBJECTIVE: To examine the risk of unexpected death in patients prescribed an antipsychotic. Unexpected death was defined as death occurring within 7 days of the onset of acute symptoms. METHOD: A case-control study conducted on events occurring between July 2009 and January 2011 in a UK mental health trust providing in-patient and out-patient services. RESULTS: The study included 100 cases (deaths) and 436 unmatched controls. Current users of antipsychotics had a lower risk of unexpected death than non-users--adjusted odds ratio (OR) 0.48 (95% CI 0.24-0.94, P = 0.033). A significant reduction in risk was seen for second-generation [adjusted OR 0.42 (95% CI 0.21-0.86, P = 0.018)], but not first-generation agents [adjusted OR 0.83 (95% CI 0.31-2.20, P = 0.706)]. Treatment with antipsychotics for any duration was associated with reduced risk. Dose and route of administration did not affect risk. In a planned secondary analysis not adjusting for cardiovascular disease, prescription of an antipsychotic was not associated with increased risk of unexpected death [adjusted OR 0.56 (95% CI 0.28-1.08, P = 0.084)]. CONCLUSION: Our findings do not support an association between current antipsychotic use and increased risk of unexpected death.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antipsicóticos / Muerte Súbita Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Acta Psychiatr Scand Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antipsicóticos / Muerte Súbita Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Acta Psychiatr Scand Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos