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Exposure to moxifloxacin and cytomegalovirus replication is associated with skin squamous cell carcinoma development in lung transplant recipients.
Gerber, S R; Seifert, B; Inci, I; Serra, A L; Kohler, M; Benden, C; Hofbauer, G F L; Schuurmans, M M.
Afiliación
  • Gerber SR; Division of Dermatology, University Hospital Zurich, Zurich, Switzerland.
  • Seifert B; Division of Pulmonology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Inci I; Epidemiology, Biostatistics, and Prevention Institute, University of Zurich, Zurich, Switzerland.
  • Serra AL; Division of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland.
  • Kohler M; Epidemiology, Biostatistics, and Prevention Institute, University of Zurich, Zurich, Switzerland.
  • Benden C; Division of Pulmonology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Hofbauer GF; Division of Pulmonology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
  • Schuurmans MM; Division of Dermatology, University Hospital Zurich, Zurich, Switzerland.
J Eur Acad Dermatol Venereol ; 29(12): 2451-7, 2015 Dec.
Article en En | MEDLINE | ID: mdl-26403508
BACKGROUND: Lung transplant recipients (LTR) are at increased risk for squamous cell carcinoma of the skin (SCC), but risk factors (RF) are incompletely understood. OBJECTIVE: To assess associations between exposure to certain medications and viral infections, and subsequent SCC development. METHODS: Retrospective study examining incidence and potential RF for SCC in LTR transplanted from 1992 to 2010 followed up at one centre. Cumulative incidence and Cox proportional hazards regression models were used to evaluate RF in the first year post-transplant for SCC formation during the follow-up. RESULTS: In 205 analysed LTR, 46 patients were diagnosed with SCC during a median follow-up of 4.9 years. The cumulative incidences of first SCC were 16.7% and 34.1%, for 5 and 10 years post-transplantation respectively. Multivariable analysis identified CMV replication (HR 7.69, 95% CI 2.93-20.2, P < 0.001) and moxifloxacin exposure (HR 2.35, 95% CI 1.15-4.81, P = 0.020) during the first year post-transplantation as independent RF for SCC development during follow-up. CONCLUSION: In our cohort, moxifloxacin use and CMV replication during the first year post-transplantation were associated with increased risk for SCC. These two factors could be indicators of over-immunosuppression. Their role in SCC development requires investigations in larger cohorts and prospective studies.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Carcinoma de Células Escamosas / Trasplante de Pulmón / Infecciones por Citomegalovirus / Fluoroquinolonas / Antibacterianos Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Eur Acad Dermatol Venereol Asunto de la revista: DERMATOLOGIA / DOENCAS SEXUALMENTE TRANSMISSIVEIS Año: 2015 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Carcinoma de Células Escamosas / Trasplante de Pulmón / Infecciones por Citomegalovirus / Fluoroquinolonas / Antibacterianos Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Eur Acad Dermatol Venereol Asunto de la revista: DERMATOLOGIA / DOENCAS SEXUALMENTE TRANSMISSIVEIS Año: 2015 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido