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Kinetics of omega-3 polyunsaturated fatty acids when co-administered with saturated or omega-6 fats.
Dias, Cintia B; Wood, Lisa G; Phang, Melinda; Garg, Manohar Lal.
Afiliación
  • Dias CB; Nutraceuticals Research Group, School of Biomedical Sciences and Pharmacy, University of Newcastle, Australia; Hunter Medical Research Institute, University of Newcastle, Australia. Electronic address: cintia.dias@uon.edu.au.
  • Wood LG; Hunter Medical Research Institute, University of Newcastle, Australia; Centre for Asthma and Respiratory Disease, School of Biomedical Sciences and Pharmacy, University of Newcastle, Australia. Electronic address: lisa.wood@newcastle.edu.au.
  • Phang M; Nutraceuticals Research Group, School of Biomedical Sciences and Pharmacy, University of Newcastle, Australia; Hunter Medical Research Institute, University of Newcastle, Australia. Electronic address: melinda.phang@health.sa.gov.au.
  • Garg ML; Nutraceuticals Research Group, School of Biomedical Sciences and Pharmacy, University of Newcastle, Australia; Hunter Medical Research Institute, University of Newcastle, Australia. Electronic address: manohar.garg@newcastle.edu.au.
Metabolism ; 64(12): 1658-66, 2015 Dec.
Article en En | MEDLINE | ID: mdl-26386693
OBJECTIVE: Absorption of long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) has been shown to be potentiated when consumed with a high fat meal. However, the effect of different dietary fats on n-3PUFA absorption and postprandial kinetics has not been previously studied. METHOD: In a randomized cross-over design intervention, postprandial incorporation of LCn-3PUFA into plasma lipids following consumption of a meal rich in either saturated fat or omega-6 polyunsaturated fatty acids (n-6PUFA) was investigated. Healthy adult male and female subjects (n=26) were fed an isocaloric meal containing equivalent amount of either butter or sunflower seed oil supplemented with 1.8grams of LCn-3PUFA (300mg eicosapentaenoic acid, 20:5n-3 and 1500mg docosahexaenoic acid, 22:6n-3). RESULTS: Postprandial plasma lipids were enriched with saturated fatty acids and linoleic acid (18:2n-6) following consumption of the butter and the sunflower oil containing meals respectively. The increase in plasma 20:5n-3 and 22:6n-3 levels over the 6hour study period was similar in both the saturated and the n-6 fat groups. CONCLUSION: These results suggest that the expected competition between LCn-3PUFA and n-6PUFA at the absorption level is unlikely; therefore competition at the enzymatic level should be primarily responsible for differences in their metabolic and clinical effects. Trial registered with the Australia New Zealand Trial registry as ACTRN12612000654853.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Grasos Omega-3 / Ácidos Grasos Omega-6 Tipo de estudio: Clinical_trials Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Metabolism Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ácidos Grasos Omega-3 / Ácidos Grasos Omega-6 Tipo de estudio: Clinical_trials Límite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Metabolism Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos