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The ERα-PI3K Cascade in Proopiomelanocortin Progenitor Neurons Regulates Feeding and Glucose Balance in Female Mice.
Zhu, Liangru; Xu, Pingwen; Cao, Xuehong; Yang, Yongjie; Hinton, Antentor Othrell; Xia, Yan; Saito, Kenji; Yan, Xiaofeng; Zou, Fang; Ding, Hongfang; Wang, Chunmei; Yan, Chunling; Saha, Pradip; Khan, Sohaib A; Zhao, Jean; Fukuda, Makoto; Tong, Qingchun; Clegg, Deborah J; Chan, Lawrence; Xu, Yong.
Afiliación
  • Zhu L; Children's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medi
  • Xu P; Children's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medi
  • Cao X; Children's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medi
  • Yang Y; Children's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medi
  • Hinton AO; Children's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medi
  • Xia Y; Children's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medi
  • Saito K; Children's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medi
  • Yan X; Children's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medi
  • Zou F; Children's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medi
  • Ding H; Children's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medi
  • Wang C; Children's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medi
  • Yan C; Children's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medi
  • Saha P; Children's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medi
  • Khan SA; Children's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medi
  • Zhao J; Children's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medi
  • Fukuda M; Children's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medi
  • Tong Q; Children's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medi
  • Clegg DJ; Children's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medi
  • Chan L; Children's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medi
  • Xu Y; Children's Nutrition Research Center (L.Z., P.X., X.C., Y.Y., A.O.H., Y.Xi., K.S., X.Y., F.Z., H.D., C.W., C.Y., M.F., Y.Xu), Department of Pediatrics; Diabetes Research Center (P.S., L.C.), Department of Medicine; and Department of Molecular and Cellular Biology (L.C., Y.Xu), Baylor College of Medi
Endocrinology ; 156(12): 4474-91, 2015 Dec.
Article en En | MEDLINE | ID: mdl-26375425
Estrogens act upon estrogen receptor (ER)α to inhibit feeding and improve glucose homeostasis in female animals. However, the intracellular signals that mediate these estrogenic actions remain unknown. Here, we report that anorexigenic effects of estrogens are blunted in female mice that lack ERα specifically in proopiomelanocortin (POMC) progenitor neurons. These mutant mice also develop insulin resistance and are insensitive to the glucose-regulatory effects of estrogens. Moreover, we showed that propyl pyrazole triol (an ERα agonist) stimulates the phosphatidyl inositol 3-kinase (PI3K) pathway specifically in POMC progenitor neurons, and that blockade of PI3K attenuates propyl pyrazole triol-induced activation of POMC neurons. Finally, we show that effects of estrogens to inhibit food intake and to improve insulin sensitivity are significantly attenuated in female mice with PI3K genetically inhibited in POMC progenitor neurons. Together, our results indicate that an ERα-PI3K cascade in POMC progenitor neurons mediates estrogenic actions to suppress food intake and improve insulin sensitivity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Proopiomelanocortina / Resistencia a la Insulina / Receptor alfa de Estrógeno / Ingestión de Alimentos / Estrógenos / Células-Madre Neurales / Fosfatidilinositol 3-Quinasa / Neuronas Límite: Animals Idioma: En Revista: Endocrinology Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Proopiomelanocortina / Resistencia a la Insulina / Receptor alfa de Estrógeno / Ingestión de Alimentos / Estrógenos / Células-Madre Neurales / Fosfatidilinositol 3-Quinasa / Neuronas Límite: Animals Idioma: En Revista: Endocrinology Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos