[Effect of cimetidine and ranitidine on bronchial reactivity in patients with asthma]. / Wplyw cymetydyny i ranitydyny na reaktywnosc drzewa oskrzelowego u chorych na dychawice oskrzelowa.
Pol Tyg Lek
; 44(27): 639-41, 1989 Jul 03.
Article
en Pl
| MEDLINE
| ID: mdl-2637435
The results of studies on the effect of cimetidine and ranitidine on the bronchial reactivity in a group of 10 patients with atopic bronchial asthma are discussed. The patients received 800 mg of cimetidine daily for 6 days and, after a three-day interval, 300 mg of ranitidine daily for a further 6 days. Bronchial reactivity was determined with the histamine test, according to Spector and Farr, before the administration of each drug and on the third and sixth days of each course of the treatment. A comparison of the effect of cimetidine and ranitidine on the bronchial reactivity in the same patients revealed that a 3-day exposure to each of the two drugs, cimetidine enhanced bronchial reactivity to a greater extent than ranitidine; the difference between the action of the two drugs being statistically significant (p less than 0.05). Bronchial reactivity was found to increase significantly after a 6-day treatment with each of the drugs but no statistically significant differences were noted comparing the effect of these drugs.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ranitidina
/
Asma
/
Bronquios
/
Cimetidina
Límite:
Humans
Idioma:
Pl
Revista:
Pol Tyg Lek
Asunto de la revista:
MEDICINA
Año:
1989
Tipo del documento:
Article
Pais de publicación:
Polonia