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Prevention of ovarian hyperstimulation syndrome in a rat model: comparison of the efficacy of tocilizumab with that of ranibizumab, cabergoline, and a gonadotropin-releasing hormone antagonist.
Taskin, Mine Islimye; Topcu, Onur; Yay, Arzu; Erken, Gulten; Balcioglu, Esra; Adali, Ertan; Hismiogullari, Adnan Adil.
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  • Taskin MI; a Department of Obstetrics and Gynecology , Balikesir University Faculty of Medicine , Balikesir , Turkey .
  • Topcu O; b Dr. Zekai Tahir Burak Women's Health Investigation and Education Hospital , Ankara , Turkey .
  • Yay A; c Department of Histology and Embryology , Erciyes University Faculty of Medicine , Kayseri , Turkey .
  • Erken G; d Department of Physiology , and.
  • Balcioglu E; c Department of Histology and Embryology , Erciyes University Faculty of Medicine , Kayseri , Turkey .
  • Adali E; a Department of Obstetrics and Gynecology , Balikesir University Faculty of Medicine , Balikesir , Turkey .
  • Hismiogullari AA; e Department of Biochemistry , Balikesir University Faculty of Medicine , Balikesir , Turkey.
Gynecol Endocrinol ; 31(12): 949-54, 2015.
Article en En | MEDLINE | ID: mdl-26369707
The aim of the study is to investigate the effects of the interleukin-6 (IL-6) blocker tocilizumab in a hyperstimulated rat model and compare it with ranibizumab, a gonadotropin-releasing hormone antagonist (GnRHA), and cabergoline. Forty-seven rats were randomly divided into the following seven groups: Group 1: OHS; Group 2: OHS+ GnRHA; Group 3: OHS + ranibizumab; Group 4: OHS + cabergoline; Group 5: OHS + low-dose tocilizumab (TL); Group 6: OHS + high-dose tocilizumab (TH); Group 7: sham. Ovarian weight was significantly lower only in the ranibizumab group than in the OHS group. Estrogen levels were significantly lower in the GnRHA group than in the OHS and the treatment groups. Progesterone levels were significantly lower in the ranibizumab, cabergoline, and TL groups than in the OHS group. Among the treatment groups, corpus luteum counts were lower than in the OHS group. Corpus luteum counts were lowest in the tocilizumab groups. IL-6 intensity was lower in all treatment groups than in the OHS group. In the ranibizumab group IL-6 intensity was the lowest. The TL group did not significantly differ from the GnRHA and cabergoline groups regarding IL-6 expression. Ovarian VEGF expression was significantly lower in all treatment groups. For the TL, ranibizumab, and cabergoline groups VEGF intensity was similar. Tocilizumab may be a new strategy for preventing ovarian hyperstimulation syndrome by inhibition of IL-6.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hormona Liberadora de Gonadotropina / Interleucina-6 / Síndrome de Hiperestimulación Ovárica / Ergolinas / Anticuerpos Monoclonales Humanizados / Ranibizumab Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Gynecol Endocrinol Asunto de la revista: ENDOCRINOLOGIA / GINECOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hormona Liberadora de Gonadotropina / Interleucina-6 / Síndrome de Hiperestimulación Ovárica / Ergolinas / Anticuerpos Monoclonales Humanizados / Ranibizumab Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Gynecol Endocrinol Asunto de la revista: ENDOCRINOLOGIA / GINECOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Reino Unido