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Using the Electronic Nose to Identify Airway Infection during COPD Exacerbations.
Shafiek, Hanaa; Fiorentino, Federico; Merino, Jose Luis; López, Carla; Oliver, Antonio; Segura, Jaume; de Paul, Ivan; Sibila, Oriol; Agustí, Alvar; Cosío, Borja G.
Afiliación
  • Shafiek H; Department of Respiratory Medicine, Hospital Universitario Son Espases. IdISPa. Palma de Mallorca, Spain; Department of Chest Diseases, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
  • Fiorentino F; Department of Respiratory Medicine, Hospital Universitario Son Espases. IdISPa. Palma de Mallorca, Spain.
  • Merino JL; Electronic Systems Group, University of the Balearic Islands (GSE-UIB), Palma de Mallorca, Spain.
  • López C; Department of Microbiology, Hospital Universitario Son Espases. IdISPa. Palma de Mallorca, Spain.
  • Oliver A; Department of Microbiology, Hospital Universitario Son Espases. IdISPa. Palma de Mallorca, Spain.
  • Segura J; Electronic Systems Group, University of the Balearic Islands (GSE-UIB), Palma de Mallorca, Spain.
  • de Paul I; Electronic Systems Group, University of the Balearic Islands (GSE-UIB), Palma de Mallorca, Spain.
  • Sibila O; Department of Respiratory Medicine, Hospital de la Santa Creu i Sant Pau, Institut d'Investigació Biomédica Sant Pau (IIB Sant Pau), Barcelona, Spain.
  • Agustí A; Thorax Institute, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain; CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain.
  • Cosío BG; Department of Respiratory Medicine, Hospital Universitario Son Espases. IdISPa. Palma de Mallorca, Spain; CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain.
PLoS One ; 10(9): e0135199, 2015.
Article en En | MEDLINE | ID: mdl-26353114
BACKGROUND: The electronic nose (e-nose) detects volatile organic compounds (VOCs) in exhaled air. We hypothesized that the exhaled VOCs print is different in stable vs. exacerbated patients with chronic obstructive pulmonary disease (COPD), particularly if the latter is associated with airway bacterial infection, and that the e-nose can distinguish them. METHODS: Smell-prints of the bacteria most commonly involved in exacerbations of COPD (ECOPD) were identified in vitro. Subsequently, we tested our hypothesis in 93 patients with ECOPD, 19 of them with pneumonia, 50 with stable COPD and 30 healthy controls in a cross-sectional case-controlled study. Secondly, ECOPD patients were re-studied after 2 months if clinically stable. Exhaled air was collected within a Tedlar bag and processed by a Cynarose 320 e-nose. Breath-prints were analyzed by Linear Discriminant Analysis (LDA) with "One Out" technique and Sensor logic Relations (SLR). Sputum samples were collected for culture. RESULTS: ECOPD with evidence of infection were significantly distinguishable from non-infected ECOPD (p = 0.018), with better accuracy when ECOPD was associated to pneumonia. The same patients with ECOPD were significantly distinguishable from stable COPD during follow-up (p = 0.018), unless the patient was colonized. Additionally, breath-prints from COPD patients were significantly distinguished from healthy controls. Various bacteria species were identified in culture but the e-nose was unable to identify accurately the bacteria smell-print in infected patients. CONCLUSION: E-nose can identify ECOPD, especially if associated with airway bacterial infection or pneumonia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacterias / Infecciones Bacterianas / Enfermedad Pulmonar Obstructiva Crónica / Compuestos Orgánicos Volátiles / Nariz Electrónica Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2015 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bacterias / Infecciones Bacterianas / Enfermedad Pulmonar Obstructiva Crónica / Compuestos Orgánicos Volátiles / Nariz Electrónica Tipo de estudio: Diagnostic_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2015 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Estados Unidos