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Neurobiological mechanisms of repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex in depression: a systematic review.
Noda, Y; Silverstein, W K; Barr, M S; Vila-Rodriguez, F; Downar, J; Rajji, T K; Fitzgerald, P B; Mulsant, B H; Vigod, S N; Daskalakis, Z J; Blumberger, D M.
Afiliación
  • Noda Y; Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health,Toronto,Ontario,Canada.
  • Silverstein WK; Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health,Toronto,Ontario,Canada.
  • Barr MS; Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health,Toronto,Ontario,Canada.
  • Vila-Rodriguez F; Non-Invasive Neurostimulation Therapies Laboratory,Department of Psychiatry,Faculty of Medicine,University of British Columbia,Vancouver,British Columbia,Canada.
  • Downar J; Department of Psychiatry,University of Toronto,Toronto,Ontario,Canada.
  • Rajji TK; Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health,Toronto,Ontario,Canada.
  • Fitzgerald PB; Monash Alfred Psychiatry Research Centre,The Alfred and Monash University Central Clinical School,Melbourne,Victoria,Australia.
  • Mulsant BH; Department of Psychiatry,University of Toronto,Toronto,Ontario,Canada.
  • Vigod SN; Department of Psychiatry,University of Toronto,Toronto,Ontario,Canada.
  • Daskalakis ZJ; Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health,Toronto,Ontario,Canada.
  • Blumberger DM; Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health,Toronto,Ontario,Canada.
Psychol Med ; 45(16): 3411-32, 2015 Dec.
Article en En | MEDLINE | ID: mdl-26349810
Depression is one of the most prevalent mental illnesses worldwide and a leading cause of disability, especially in the setting of treatment resistance. In recent years, repetitive transcranial magnetic stimulation (rTMS) has emerged as a promising alternative strategy for treatment-resistant depression and its clinical efficacy has been investigated intensively across the world. However, the underlying neurobiological mechanisms of the antidepressant effect of rTMS are still not fully understood. This review aims to systematically synthesize the literature on the neurobiological mechanisms of treatment response to rTMS in patients with depression. Medline (1996-2014), Embase (1980-2014) and PsycINFO (1806-2014) were searched under set terms. Three authors reviewed each article and came to consensus on the inclusion and exclusion criteria. All eligible studies were reviewed, duplicates were removed, and data were extracted individually. Of 1647 articles identified, 66 studies met both inclusion and exclusion criteria. rTMS affects various biological factors that can be measured by current biological techniques. Although a number of studies have explored the neurobiological mechanisms of rTMS, a large variety of rTMS protocols and parameters limits the ability to synthesize these findings into a coherent understanding. However, a convergence of findings suggest that rTMS exerts its therapeutic effects by altering levels of various neurochemicals, electrophysiology as well as blood flow and activity in the brain in a frequency-dependent manner. More research is needed to delineate the neurobiological mechanisms of the antidepressant effect of rTMS. The incorporation of biological assessments into future rTMS clinical trials will help in this regard.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Prefrontal / Depresión / Estimulación Magnética Transcraneal / Trastorno Depresivo Resistente al Tratamiento / Antidepresivos Tipo de estudio: Clinical_trials / Guideline / Prognostic_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Psychol Med Año: 2015 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Corteza Prefrontal / Depresión / Estimulación Magnética Transcraneal / Trastorno Depresivo Resistente al Tratamiento / Antidepresivos Tipo de estudio: Clinical_trials / Guideline / Prognostic_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Psychol Med Año: 2015 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido