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Successful treatment of paroxysmal tonic spasms with topiramate in a patient with neuromyelitis optica.
Iida, Shin; Nakamura, Masataka; Wate, Reika; Kaneko, Satoshi; Kusaka, Hirofumi.
Afiliación
  • Iida S; Department of Neurology, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka 5731010, Japan.
  • Nakamura M; Department of Neurology, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka 5731010, Japan.
  • Wate R; Department of Neurology, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka 5731010, Japan.
  • Kaneko S; Department of Neurology, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka 5731010, Japan. Electronic address: kanekosa@takii.kmu.ac.jp.
  • Kusaka H; Department of Neurology, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka 5731010, Japan.
Mult Scler Relat Disord ; 4(5): 457-459, 2015 Sep.
Article en En | MEDLINE | ID: mdl-26346795
A 49-year-old woman with neuromyelitis optica (NMO) developed severe quadriplegia and frequent paroxysmal tonic spasms (PTS). Carbamazepine, although initially effective against PTS, caused drug eruption and she was unable to continue. PTS re-emerged after discontinuation of carbamazepine and hindered rehabilitation. Then topiramate was started, and PTS promptly disappeared. The patient became able to resume rehabilitation and her activity of daily life improved significantly. Carbamazepine and topiramate have a common pharmacological action to block voltage-gated sodium channels. The action may have contributed to inhibition of ephaptic transmission in the demyelinating lesions by NMO and eventually improved PTS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neuromielitis Óptica / Distonía / Fructosa / Anticonvulsivantes Límite: Female / Humans / Middle aged Idioma: En Revista: Mult Scler Relat Disord Año: 2015 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neuromielitis Óptica / Distonía / Fructosa / Anticonvulsivantes Límite: Female / Humans / Middle aged Idioma: En Revista: Mult Scler Relat Disord Año: 2015 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos