Your browser doesn't support javascript.
loading
Associations between the SRD5A2 gene V89L and TA repeat polymorphisms and breast cancer risk: a meta-analysis.
Zhang, D; Li, Q; Qu, H-C; Yu, T; Liu, Y-R.
Afiliación
  • Zhang D; College of Basic Medical Science, China Medical University, Shenyang, Liaoning, China.
  • Li Q; Laboratory Center, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
  • Qu HC; Department of Urological Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
  • Yu T; Laboratory Center, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
  • Liu YR; College of Basic Medical Science, China Medical University, Shenyang, Liaoning, China.
Genet Mol Res ; 14(3): 9004-12, 2015 Aug 07.
Article en En | MEDLINE | ID: mdl-26345832
The 5α-reductase type 2 (SRD5A2) gene plays a significant role in the development of breast cancer. The V89L and TA repeat polymorphisms of the SRD5A2 gene have been considered as risk factors for breast cancer. However, the results have been inconsistent. To resolve this conflict, we performed a meta-analysis of studies with V89L (1144 patients and 808 controls) and with TA repeat genotyping (1952 cases and 1008 controls). The associations were evaluated by calculating odds ratios (ORs) and 95% confidence intervals (CIs). The result showed that there was no relationship between the V89L polymorphism of the SRD5A2 gene (V/V versus V/L + L/L genotypes) and breast cancer susceptibility (OR = 1.21; 95%CI = 0.99-1.47; P = 0.28). In addition, there was no difference between patients with breast cancer and healthy people in the distributions of the L allele (OR = 1.06; 95%CI = 0.75-1.49; P = 0.003). Similarly, no significant association between the SRDA5A2 TA repeat polymorphism and breast cancer risk was discovered. The comparison of (TA)0/(TA)0versus (TA)0/(TA)9 + (TA)9/(TA)9 genotypes found no difference in the risk of breast cancer (OR = 0.91; 95%CI = 0.66-1.25; P = 0.05). The OR for the (TA)0 versus (TA)9 allele was 0.89 (95%CI = 0.67-1.19). In conclusion, the V89L and TA repeat polymorphisms of SRD5A2 gene were found to have no significant associations with breast cancer risk.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: 3-Oxo-5-alfa-Esteroide 4-Deshidrogenasa / Neoplasias de la Mama / Predisposición Genética a la Enfermedad / Proteínas de la Membrana Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Female / Humans Idioma: En Revista: Genet Mol Res Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: Brasil
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: 3-Oxo-5-alfa-Esteroide 4-Deshidrogenasa / Neoplasias de la Mama / Predisposición Genética a la Enfermedad / Proteínas de la Membrana Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Female / Humans Idioma: En Revista: Genet Mol Res Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: Brasil