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Clinical subsets associated with different anti-aminoacyl transfer RNA synthetase antibodies and their association with coexisting anti-Ro52.
Yamasaki, Yoshioki; Satoh, Minoru; Mizushima, Machiko; Okazaki, Takahiro; Nagafuchi, Hiroko; Ooka, Seido; Shibata, Tomohiko; Nakano, Hiromasa; Ogawa, Hitoshi; Azuma, Kohei; Maeda, Akihiko; Tonooka, Kumiko; Ito, Hiroshi; Takakuwa, Yukiko; Inoue, Makoto; Mitomi, Hirofumi; Kiyokawa, Tomofumi; Tsuchida, Kosei; Matsushita, Hiromi; Mikage, Hidenori; Murakami, Yoshihiko; Chan, Jason Y F; Ozaki, Shoichi; Yamada, Hidehiro.
Afiliación
  • Yamasaki Y; a Division of Rheumatology and Allergology, Department of Internal Medicine , St. Marianna University School of Medicine , Kawasaki , Japan .
  • Satoh M; b Department of Clinical Nursing, School of Health Sciences , University of Occupational and Environmental Health , Kitakyushu , Japan .
  • Mizushima M; c Division of Rheumatology and Clinical Immunology, Department of Medicine , University of Florida , Gainesville , FL , USA , and.
  • Okazaki T; a Division of Rheumatology and Allergology, Department of Internal Medicine , St. Marianna University School of Medicine , Kawasaki , Japan .
  • Nagafuchi H; a Division of Rheumatology and Allergology, Department of Internal Medicine , St. Marianna University School of Medicine , Kawasaki , Japan .
  • Ooka S; a Division of Rheumatology and Allergology, Department of Internal Medicine , St. Marianna University School of Medicine , Kawasaki , Japan .
  • Shibata T; a Division of Rheumatology and Allergology, Department of Internal Medicine , St. Marianna University School of Medicine , Kawasaki , Japan .
  • Nakano H; d Division of Rheumatology, Department of Internal Medicine , Yokohama City Seibu Hospital, St. Marianna University School of Medicine , Yokohama , Japan.
  • Ogawa H; a Division of Rheumatology and Allergology, Department of Internal Medicine , St. Marianna University School of Medicine , Kawasaki , Japan .
  • Azuma K; a Division of Rheumatology and Allergology, Department of Internal Medicine , St. Marianna University School of Medicine , Kawasaki , Japan .
  • Maeda A; a Division of Rheumatology and Allergology, Department of Internal Medicine , St. Marianna University School of Medicine , Kawasaki , Japan .
  • Tonooka K; a Division of Rheumatology and Allergology, Department of Internal Medicine , St. Marianna University School of Medicine , Kawasaki , Japan .
  • Ito H; a Division of Rheumatology and Allergology, Department of Internal Medicine , St. Marianna University School of Medicine , Kawasaki , Japan .
  • Takakuwa Y; a Division of Rheumatology and Allergology, Department of Internal Medicine , St. Marianna University School of Medicine , Kawasaki , Japan .
  • Inoue M; a Division of Rheumatology and Allergology, Department of Internal Medicine , St. Marianna University School of Medicine , Kawasaki , Japan .
  • Mitomi H; a Division of Rheumatology and Allergology, Department of Internal Medicine , St. Marianna University School of Medicine , Kawasaki , Japan .
  • Kiyokawa T; a Division of Rheumatology and Allergology, Department of Internal Medicine , St. Marianna University School of Medicine , Kawasaki , Japan .
  • Tsuchida K; a Division of Rheumatology and Allergology, Department of Internal Medicine , St. Marianna University School of Medicine , Kawasaki , Japan .
  • Matsushita H; a Division of Rheumatology and Allergology, Department of Internal Medicine , St. Marianna University School of Medicine , Kawasaki , Japan .
  • Mikage H; a Division of Rheumatology and Allergology, Department of Internal Medicine , St. Marianna University School of Medicine , Kawasaki , Japan .
  • Murakami Y; a Division of Rheumatology and Allergology, Department of Internal Medicine , St. Marianna University School of Medicine , Kawasaki , Japan .
  • Chan JY; a Division of Rheumatology and Allergology, Department of Internal Medicine , St. Marianna University School of Medicine , Kawasaki , Japan .
  • Ozaki S; c Division of Rheumatology and Clinical Immunology, Department of Medicine , University of Florida , Gainesville , FL , USA , and.
  • Yamada H; a Division of Rheumatology and Allergology, Department of Internal Medicine , St. Marianna University School of Medicine , Kawasaki , Japan .
Mod Rheumatol ; 26(3): 403-9, 2016.
Article en En | MEDLINE | ID: mdl-26344678
OBJECTIVE: To characterize clinical features of polymyositis/dermatomyositis (PM/DM) patients with different anti-aminoacyl transfer RNA synthetase (ARS) antibodies and their association with anti-Ro52. METHODS: Autoantibodies in sera from 97 Japanese patients (36 PM, 56 DM, and 5 clinically amyopathic DM), who satisfied Bohan and Peter or modified Sontheimer's criteria, were characterized by immunoprecipitation and enzyme-linked immunosorbent assay. Clinical information was from medical records. Features associated with different anti-ARS and anti-Ro52 antibodies were analyzed. RESULTS: The prevalence of anti-ARS was similar to other studies (Jo-1, 22%; EJ, 4%; OJ, 1%; PL-12, 1%), except for a high prevalence of anti-PL-7 (12%), which allowed us to characterize patients carrying this specificity. Serum creatine kinase >3000 IU/l was less common in anti-PL-7-positive patients (57%) than anti-Jo-1-positive patients (18%) (p = 0.0328) and was not found in anti-EJ-positive individuals. Interstitial lung disease was common in anti-ARS-positive patients (97%) (p < 0.0001 vs. 48% in anti-ARS-negative). Anti-Ro52 antibodies were frequently detected with anti-ARS (59%) (57% in anti-Jo-1, 67% in anti-PL-7) (vs. 21% in anti-ARS-negative, p < 0.0002). Anti-Ro52 was associated with overlap syndrome (26%) (vs. 7% in anti-Ro52-negative, p = 0.0119). CONCLUSIONS: Patients with different anti-ARS in combination with anti-Ro52 appear to be associated with distinctive clinical subsets.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ribonucleoproteínas / Autoanticuerpos / Enfermedades Autoinmunes / Dermatomiositis / Aminoacil-ARNt Sintetasas Tipo de estudio: Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Mod Rheumatol Año: 2016 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ribonucleoproteínas / Autoanticuerpos / Enfermedades Autoinmunes / Dermatomiositis / Aminoacil-ARNt Sintetasas Tipo de estudio: Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Mod Rheumatol Año: 2016 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido