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Micronucleus testing as a cancer detector: endometrial hyperplasia to carcinoma.
Kiraz, Aslihan; Açmaz, Gokhan; Uysal, Gulsum; Unal, Dilek; Dönmez-Altuntas, Hamiyet.
Afiliación
  • Kiraz A; Department of Medical Genetics, Education and Research Hospital, 38210, Kayseri, Turkey. aslihankiraz@gmail.com.
  • Açmaz G; Department of Gynecology, Education and Research Hospital, Kayseri, Turkey.
  • Uysal G; Department of Gynecology, Education and Research Hospital, Kayseri, Turkey.
  • Unal D; Department of Radiation Oncology, Education and Research Hospital, Kayseri, Turkey.
  • Dönmez-Altuntas H; Department of Medical Biology, Faculty of Medicine, Erciyes University, Kayseri, Turkey.
Arch Gynecol Obstet ; 293(5): 1065-71, 2016 May.
Article en En | MEDLINE | ID: mdl-26342824
PURPOSE: Endometrium carcinoma (EC) is the fourth common cancer among women worldwide and the incidence is increasing. It is important to define the EC earlier for survival of the patients. METHODS: Women who had endometrial hyperplasia (EH) and EC in postmenopausal and premenopausal period were included to participate in this study. MN assay has been performed to participants for detection of the genetic damages and DNA instability. RESULTS: MN ratio was significantly higher in EC group compared to other two groups (EH and control groups) (p < 0.001). On the other hand, there was no significant difference among these groups with regard to number of gravidity and presence of a family history of cancer (p > 0.05). MN frequency and NDI were significantly correlated with the age in endometrial hyperplasia without atypia, endometrial cancer and control groups (r 0.546, p < 0.001; r 0.320, p 0.024; r 0.396, p 0.003, respectively). Similarly, MN frequency and NDI were significantly correlated with BMI in three groups (r 0.287, p 0.044; r 0.467, p 0.001; r 0.473, p 0.001, respectively). CONCLUSIONS: MN scoring in pre-neoplastic conditions of the endometrium can be used as adjunct in endometrium cancer screening. By using MN assay, discrimination may be possible among endometrial cancer, endometrial precancerous lesions and pathologically normal patients. This is an easy, simple, reliable, reproducible objective test and can be used in routine patient examination.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas de Micronúcleos / Neoplasias Endometriales / Hiperplasia Endometrial / Endometrio Límite: Adult / Aged / Female / Humans / Middle aged País/Región como asunto: Asia Idioma: En Revista: Arch Gynecol Obstet Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2016 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas de Micronúcleos / Neoplasias Endometriales / Hiperplasia Endometrial / Endometrio Límite: Adult / Aged / Female / Humans / Middle aged País/Región como asunto: Asia Idioma: En Revista: Arch Gynecol Obstet Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2016 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Alemania