Pharmacokinetics and metabolism of 14C isobytylnaphtyl acetic acid in rat.
Eur J Drug Metab Pharmacokinet
; 14(4): 249-56, 1989.
Article
en En
| MEDLINE
| ID: mdl-2633918
After oral administration to rats, absorption of INAA was slow but complete. Plasma level curves reached a plateau for INAA as well as for the two metabolites, which were rapidly formed (MI and MII). The plateau concentration led to an increase of the apparent elimination half-life, which was short after i.v. administration due to the small volume of distribution and to the high rate of metabolism. In any case the half-life was independent of the dose and the pharmacokinetics of INAA remained linear from 1.5 to 15 mg/kg. The two rapidly formed plasma metabolites were eliminated more slowly than INAA. INAA and its metabolites were distributed only sparsely in all tissues under investigation, probably due to the high protein binding. Both routes of administration resulted in elimination of the radioactivity mainly by the urine. Besides the two main metabolites with known structures (MI and MII) small amounts of INAA and two additional metabolites were detected.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Ácidos Naftalenoacéticos
Límite:
Animals
Idioma:
En
Revista:
Eur J Drug Metab Pharmacokinet
Año:
1989
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Francia