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PEG-Phospholipids Coated Quantum Rods as Amplifiers of the Photosensitization Process by FRET.
Timor, Reut; Weitman, Hana; Waiskopf, Nir; Banin, Uri; Ehrenberg, Benjamin.
Afiliación
  • Timor R; Department of Physics and Institute of Nanotechnology and Advanced Materials, Bar Ilan University , Ramat Gan 52900, Israel.
  • Weitman H; Department of Physics and Institute of Nanotechnology and Advanced Materials, Bar Ilan University , Ramat Gan 52900, Israel.
  • Waiskopf N; Institute of Chemistry and Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem , Jerusalem 91904, Israel.
  • Banin U; Institute of Chemistry and Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem , Jerusalem 91904, Israel.
  • Ehrenberg B; Department of Physics and Institute of Nanotechnology and Advanced Materials, Bar Ilan University , Ramat Gan 52900, Israel.
ACS Appl Mater Interfaces ; 7(38): 21107-14, 2015 Sep 30.
Article en En | MEDLINE | ID: mdl-26334672
Singlet oxygen ((1)O2) generated upon photostimulation of photosensitizer molecules is a highly reactive specie which is utilized in photodynamic therapy. Recent studies have shown that semiconductor nanoparticles can be used as donors in fluorescence resonance energy transfer (FRET) process to excite attached photosensitizer molecules. In these studies, their unique properties, such as low nanoscale size, long-term photostability, wide broad absorbance band, large absorption cross section, and narrow and tunable emission bands were used to provide advantages over the traditional methods to produce singlet oxygen. Previous studies that achieved this goal, however, showed some limitations, such as low FRET efficiency, poor colloidal stability, nonspecific interactions, and/or complex preparation procedure. In this work, we developed and characterized a novel system of semiconductor quantum rods (QRs) and the photosensitizer meso-tetra(hydroxyphenyl) chlorin (mTHPC), as a model system that produces singlet oxygen without these limitations. A simple two-step preparation method is shown; Hydrophobic CdSe/CdS QRs are solubilized in aqueous solutions by encapsulation with lecithin and PEGylated phospholipid (PEG-PL) of two lipid lengths: PEG350 or PEG2000. Then, the hydrophobic photosensitizer mTHPC, was intercalated into the new amphiphilic PEG-PL coating of the QR, providing a strong attachment to the nanoparticle without covalent linkage. These PEGylated QR (eQR)-mTHPC nanocomposites show efficient FRET processes upon light stimulation of the QR component which results in efficient production of singlet oxygen. The results demonstrate the potential for future use of this concept in photodynamic therapy schemes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfolípidos / Polietilenglicoles / Fármacos Fotosensibilizantes / Transferencia Resonante de Energía de Fluorescencia / Puntos Cuánticos Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2015 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfolípidos / Polietilenglicoles / Fármacos Fotosensibilizantes / Transferencia Resonante de Energía de Fluorescencia / Puntos Cuánticos Idioma: En Revista: ACS Appl Mater Interfaces Asunto de la revista: BIOTECNOLOGIA / ENGENHARIA BIOMEDICA Año: 2015 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Estados Unidos