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Phylogenomic analysis reveals ancient segmental duplications in the human genome.
Hafeez, Madiha; Shabbir, Madiha; Altaf, Fouzia; Abbasi, Amir Ali.
Afiliación
  • Hafeez M; National Center for Bioinformatics, Program of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan.
  • Shabbir M; National Center for Bioinformatics, Program of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan.
  • Altaf F; National Center for Bioinformatics, Program of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan.
  • Abbasi AA; National Center for Bioinformatics, Program of Comparative and Evolutionary Genomics, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 45320, Pakistan. Electronic address: abbasiam@qau.edu.pk.
Mol Phylogenet Evol ; 94(Pt A): 95-100, 2016 Jan.
Article en En | MEDLINE | ID: mdl-26327327
Evolution of organismal complexity and origin of novelties during vertebrate history has been widely explored in context of both regulation of gene expression and gene duplication events. Ohno (1970) for the first time put forward the idea of two rounds whole genome duplication events as the most plausible explanation for evolutionarizing the vertebrate lineage (2R hypothesis). To test the validity of 2R hypothesis, a robust phylogenomic analysis of multigene families with triplicated or quadruplicated representation on human FGFR bearing chromosomes (4/5/8/10) was performed. Topology comparison approach categorized members of 80 families into five distinct co-duplicated groups. Genes belonging to one co-duplicated group are duplicated concurrently, whereas genes of two different co-duplicated groups do not share their duplication history and have not duplicated in congruency. Our findings contradict the 2R model and are indicative of small-scale duplications and rearrangements that cover the entire span of animal's history.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / Genoma Humano / Evolución Molecular / Duplicación de Gen / Duplicaciones Segmentarias en el Genoma Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Mol Phylogenet Evol Asunto de la revista: BIOLOGIA / BIOLOGIA MOLECULAR Año: 2016 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / Genoma Humano / Evolución Molecular / Duplicación de Gen / Duplicaciones Segmentarias en el Genoma Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Mol Phylogenet Evol Asunto de la revista: BIOLOGIA / BIOLOGIA MOLECULAR Año: 2016 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Estados Unidos