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Impact of time from diagnosis to initiation of curative-intent chemotherapy on clinical outcomes in patients with classical Hodgkin lymphoma.
Brooks, Edward G; Connors, Joseph M; Sehn, Laurie H; Gascoyne, Randy D; Savage, Kerry J; Shenkier, Tamara N; Klasa, Richard; Gerrie, Alina S; Skinnider, Brian; Slack, Graham W; Villa, Diego.
Afiliación
  • Brooks EG; a Faculty of Medicine , University of British Columbia , Vancouver , BC , Canada .
  • Connors JM; b Centre for Lymphoid Cancer, British Columbia Cancer Agency , Vancouver , BC , Canada , and.
  • Sehn LH; b Centre for Lymphoid Cancer, British Columbia Cancer Agency , Vancouver , BC , Canada , and.
  • Gascoyne RD; b Centre for Lymphoid Cancer, British Columbia Cancer Agency , Vancouver , BC , Canada , and.
  • Savage KJ; b Centre for Lymphoid Cancer, British Columbia Cancer Agency , Vancouver , BC , Canada , and.
  • Shenkier TN; b Centre for Lymphoid Cancer, British Columbia Cancer Agency , Vancouver , BC , Canada , and.
  • Klasa R; b Centre for Lymphoid Cancer, British Columbia Cancer Agency , Vancouver , BC , Canada , and.
  • Gerrie AS; b Centre for Lymphoid Cancer, British Columbia Cancer Agency , Vancouver , BC , Canada , and.
  • Skinnider B; c Leukemia/Bone Marrow Transplant Program of British Columbia , Vancouver , BC , Canada.
  • Slack GW; b Centre for Lymphoid Cancer, British Columbia Cancer Agency , Vancouver , BC , Canada , and.
  • Villa D; b Centre for Lymphoid Cancer, British Columbia Cancer Agency , Vancouver , BC , Canada , and.
Leuk Lymphoma ; 57(4): 872-9, 2016.
Article en En | MEDLINE | ID: mdl-26325236
The impact of treatment delays on outcomes in Hodgkin lymphoma (HL) is currently unknown. Time from definitive histologic diagnosis to first ABVD treatment (TDT) was calculated in 810 adults with HL: 365 (45%) TDT ≤4 weeks, 369 (46%) TDT 5-8 weeks, 76 (9%) TDT >8 weeks. The 5-year overall survival (OS) was 92% TDT ≤4 weeks, 92% TDT 5-8 weeks, and 83% TDT >8 weeks (p = 0.007). The 5-year disease-specific survival (DSS) was 93% TDT ≤4 weeks, 95% TDT 5-8 weeks, and 87% TDT >8 weeks (p = 0.094). The 5-year progression-free survival (PFS) was similar between groups (p = 0.139). In the multivariate analysis, TDT >8 weeks was not associated with worse OS, DSS, or PFS. Despite the univariate association between initiation of ABVD >8 weeks and worse OS, these data do not support such cut-off to improve outcomes. Nevertheless, clinicians should make every effort possible to initiate curative-intent chemotherapy as soon as a diagnosis of HL is established.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Hodgkin / Tiempo de Tratamiento Tipo de estudio: Diagnostic_studies / Etiology_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Leuk Lymphoma Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2016 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Hodgkin / Tiempo de Tratamiento Tipo de estudio: Diagnostic_studies / Etiology_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Leuk Lymphoma Asunto de la revista: HEMATOLOGIA / NEOPLASIAS Año: 2016 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos