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GS-5806 inhibits pre- to postfusion conformational changes of the respiratory syncytial virus fusion protein.
Samuel, Dharmaraj; Xing, Weimei; Niedziela-Majka, Anita; Wong, Jinny S; Hung, Magdeleine; Brendza, Katherine M; Perron, Michel; Jordan, Robert; Sperandio, David; Liu, Xiaohong; Mackman, Richard; Sakowicz, Roman.
Afiliación
  • Samuel D; Gilead Sciences, Inc., Foster City, California, USA dharmaraj.samuel@pfizer.com.
  • Xing W; Gilead Sciences, Inc., Foster City, California, USA.
  • Niedziela-Majka A; Gilead Sciences, Inc., Foster City, California, USA.
  • Wong JS; Gladstone Institutes, University of California, San Francisco, California, USA.
  • Hung M; Gilead Sciences, Inc., Foster City, California, USA.
  • Brendza KM; Gilead Sciences, Inc., Foster City, California, USA.
  • Perron M; Gilead Sciences, Inc., Foster City, California, USA.
  • Jordan R; Gilead Sciences, Inc., Foster City, California, USA.
  • Sperandio D; Gilead Sciences, Inc., Foster City, California, USA.
  • Liu X; Gilead Sciences, Inc., Foster City, California, USA.
  • Mackman R; Gilead Sciences, Inc., Foster City, California, USA.
  • Sakowicz R; Gilead Sciences, Inc., Foster City, California, USA.
Antimicrob Agents Chemother ; 59(11): 7109-12, 2015 Nov.
Article en En | MEDLINE | ID: mdl-26324264
GS-5806 is a small-molecule inhibitor of human respiratory syncytial virus fusion protein-mediated viral entry. During viral entry, the fusion protein undergoes major conformational changes, resulting in fusion of the viral envelope with the host cell membrane. This process is reproduced in vitro using a purified, truncated respiratory syncytial virus (RSV) fusion protein. GS-5806 blocked these conformational changes, suggesting a possible mechanism for antiviral activity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Pirazoles / Sulfonamidas / Proteínas Virales / Virus Sincitial Respiratorio Humano Idioma: En Revista: Antimicrob Agents Chemother Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Pirazoles / Sulfonamidas / Proteínas Virales / Virus Sincitial Respiratorio Humano Idioma: En Revista: Antimicrob Agents Chemother Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos