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Continuous and convergent access to vicinyl amino alcohols.
Nobuta, Tomoya; Xiao, Guozhi; Ghislieri, Diego; Gilmore, Kerry; Seeberger, Peter H.
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  • Nobuta T; Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany. kerry.gilmore@mpikg.mpg.de peter.seeberger@mpikg.mpg.de.
Chem Commun (Camb) ; 51(82): 15133-6, 2015 Oct 21.
Article en En | MEDLINE | ID: mdl-26324053
Five active pharmaceutical ingredients (APIs) containing the vicinyl amino alcohol moiety were synthesized using a convergent chemical assembly system. The continuous system is composed of four flow reaction modules: biphasic oxidation, Corey-Chaykovsky epoxidation, phenol alkylation, and epoxide aminolysis. Judicious choice of reagents and module order allowed for two classes of ß-amino alcohols, aryl and aryloxy, to be synthesized in good (27-69%) overall yields.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoxipropanolaminas Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fenoxipropanolaminas Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido