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The effect of ubiquinone and combined antioxidant therapy on oxidative stress markers in non-proliferative diabetic retinopathy: A phase IIa, randomized, double-blind, and placebo-controlled study.
Rodríguez-Carrizalez, Adolfo Daniel; Castellanos-González, José Alberto; Martínez-Romero, Esaú César; Miller-Arrevillaga, Guillermo; Pacheco-Moisés, Fermín Paul; Román-Pintos, Luis Miguel; Miranda-Díaz, Alejandra Guillermina.
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  • Rodríguez-Carrizalez AD; a Department of Physiology , Clinical and Experimental Treatment Institute, University Health Sciences Centre, University of Guadalajara,  Mexico (Instituto de Terapéutica Experimental y Clínica, Departamento de Fisiología).
  • Castellanos-González JA; b Department of Ophthalmology , Specialties Hospital of the National Occidental Medical Centre, Mexican Social Security Institute, Mexico (Hospital de Especialidades del Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social).
  • Martínez-Romero EC; b Department of Ophthalmology , Specialties Hospital of the National Occidental Medical Centre, Mexican Social Security Institute, Mexico (Hospital de Especialidades del Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social).
  • Miller-Arrevillaga G; b Department of Ophthalmology , Specialties Hospital of the National Occidental Medical Centre, Mexican Social Security Institute, Mexico (Hospital de Especialidades del Centro Médico Nacional de Occidente, Instituto Mexicano del Seguro Social).
  • Pacheco-Moisés FP; c University Centre of Exact and Engineering Sciences, University of Guadalajara, Mexico (Centro Universitario de Ciencias Exactas e Ingeniería).
  • Román-Pintos LM; a Department of Physiology , Clinical and Experimental Treatment Institute, University Health Sciences Centre, University of Guadalajara,  Mexico (Instituto de Terapéutica Experimental y Clínica, Departamento de Fisiología).
  • Miranda-Díaz AG; a Department of Physiology , Clinical and Experimental Treatment Institute, University Health Sciences Centre, University of Guadalajara,  Mexico (Instituto de Terapéutica Experimental y Clínica, Departamento de Fisiología).
Redox Rep ; 21(4): 155-63, 2016 Jul.
Article en En | MEDLINE | ID: mdl-26321469
Objective To evaluate the effect of ubiquinone (Coenzyme Q10) and combined antioxidant therapy (CAT) on oxidative stress markers in non-proliferative diabetic retinopathy (NPDR) under clinical management. Study design In a randomized, double-blind, phase IIa, placebo-controlled, clinical trial, three study groups were formed and administered medications as follows: Group 1, Coenzyme Q10; Group 2, CAT; and Group 3, placebo. Methods Serum levels of the products of lipid peroxidation (LPO) and nitrites/nitrates, as markers of oxidative/nitrosative stress, were measured. As antioxidants, the total antioxidant capacity (TAC), catalase activity, and glutathione peroxidase (GPx) activity were measured. Results Baseline serum levels of LPO and nitrites/nitrates were significantly elevated in the three groups vs. healthy group (P < 0.0001), while final levels in the Coenzyme Q10 and CAT groups were decreased vs. normal levels (P < 0.0001). The baseline TAC was consumed in the three groups (P < 0.0001), while final results in the Coenzyme Q10 and CAT groups improved (P < 0.0001). Baseline catalase activity was increased in all groups vs. normal values (P < 0.001), while final levels in the Coenzyme Q10 (P < 0.001) and CAT groups (P < 0.0001) were decreased. GPx behaved similarly to catalase and improved in the final results (P < 0.0001). Discussion Adjunctive antioxidant treatment for 6 months was effective and safe for improving the oxidative stress in NPDR.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ubiquinona / Retinopatía Diabética / Antioxidantes Tipo de estudio: Clinical_trials Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Redox Rep Asunto de la revista: BIOQUIMICA / METABOLISMO Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ubiquinona / Retinopatía Diabética / Antioxidantes Tipo de estudio: Clinical_trials Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Redox Rep Asunto de la revista: BIOQUIMICA / METABOLISMO Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido