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HPV vaccines: their pathology-based discovery, benefits, and adverse effects.
Nicol, Alcina F; de Andrade, Cecilia V; Russomano, Fabio B; Rodrigues, Luana S L; Oliveira, Nathalia S; Provance, David William; Nuovo, Gerard J.
Afiliación
  • Nicol AF; Laboratório Interdisciplinar de Pesquisas Médicas, IOC, Fiocruz, Rio de Janeiro, Brasil.
  • de Andrade CV; Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira - Fundação Oswaldo Cruz.
  • Russomano FB; Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira - Fundação Oswaldo Cruz.
  • Rodrigues LS; Instituto de Saúde Coletiva, Universidade Federal do Oeste do Pará and Post-graduate Student at Medicina Tropical - IOC - Fiocruz - Rio de Janeiro, Brasil.
  • Oliveira NS; Laboratório Interdisciplinar de Pesquisas Médicas, IOC, Fiocruz, Rio de Janeiro, Brasil.
  • Provance DW; Center for Technology Development in Health (CDTS)/(INCT-IDPN)-Fiocruz, Brazil.
  • Nuovo GJ; Ohio State University Comprehensive Cancer Center, Columbus, OH, USA. Electronic address: nuovo.1@osu.edu.
Ann Diagn Pathol ; 19(6): 418-22, 2015 Dec.
Article en En | MEDLINE | ID: mdl-26321154
The discovery of the human papillomavirus (HPV) vaccine illustrates the power of in situ-based pathologic analysis in better understanding and curing diseases. The 2 available HPV vaccines have markedly reduced the incidence of cervical intraepithelial neoplasias, genital warts, and cervical cancer throughout the world. Concerns about HPV vaccine safety have led some physicians, health care officials, and parents to refuse providing the recommended vaccination to the target population. The aims of the study were to discuss the discovery of HPV vaccine and review scientific data related to measurable outcomes from the use of HPV vaccines. The strong type-specific immunity against HPV in humans has been known for more than 25 years. Multiple studies confirm the positive risk benefit of HPV vaccination with minimal documented adverse effects. The most common adverse effect, injection site pain, occurred in about 10% of girls and was less than the rate reported for other vaccines. Use of HPV vaccine should be expanded into more diverse populations, mainly in low-resource settings.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Condiloma Acuminado / Displasia del Cuello del Útero / Neoplasias del Cuello Uterino / Vacunación / Infecciones por Papillomavirus / Vacunas contra Papillomavirus Límite: Female / Humans / Male Idioma: En Revista: Ann Diagn Pathol Asunto de la revista: PATOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Condiloma Acuminado / Displasia del Cuello del Útero / Neoplasias del Cuello Uterino / Vacunación / Infecciones por Papillomavirus / Vacunas contra Papillomavirus Límite: Female / Humans / Male Idioma: En Revista: Ann Diagn Pathol Asunto de la revista: PATOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos