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Group A streptococcal meningitis: emm type distribution and theoretical vaccine coverage in children.
Tuerlinckx, David; Gueulette, Emmanuelle; Loens, Katherine; Goossens, Herman; Smeesters, Pierre Robert.
Afiliación
  • Tuerlinckx D; a CHU Dinant-Godinne , Service de Pédiatrie, Université Catholique de Louvain , Yvoir , Belgium.
  • Gueulette E; b Clinique et Maternité St Elisabeth , Service de Pédiatrie , Namur , Belgium.
  • Loens K; c Department of Microbiology , University Hospital Antwerp , Belgium.
  • Goossens H; c Department of Microbiology , University Hospital Antwerp , Belgium.
  • Smeesters PR; d Group A Streptococcus Research Group , Murdoch Childrens Research Institute , Melbourne , VIC , Australia.
Acta Clin Belg ; 71(3): 138-41, 2016 Jun.
Article en En | MEDLINE | ID: mdl-26319426
As group A Streptococcus (GAS) meningitis is seldom reported in children, emm-type distribution data are scare. We report eight cases of GAS meningitis in Belgium (2008-2013) and compare molecular characteristics of our strains with a further 55 cases previously reported with their corresponding emm-types. emm1 type was the most frequent (24%) followed by emm6 (11%), emm12 (11%) and emm3 (6%). Together these four emm-types accounted for 52% of the cases, while the rest of the cases are due to 24 different emm-types. These 28 emm-types associated with GAS meningitis belonged to 16 different emm-clusters suggesting that there is no propensity for particular emm-types or emm-cluster to cause meningitis. Theoretical coverage of the 30-valent vaccine candidate would be 77.8% (49/63 isolates) among children with GAS meningitis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estreptocócicas / Streptococcus pyogenes / Proteínas de la Membrana Bacteriana Externa / Proteínas Portadoras / Meningitis Bacterianas / Vacunas Estreptocócicas / Antígenos Bacterianos Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Europa Idioma: En Revista: Acta Clin Belg Año: 2016 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Estreptocócicas / Streptococcus pyogenes / Proteínas de la Membrana Bacteriana Externa / Proteínas Portadoras / Meningitis Bacterianas / Vacunas Estreptocócicas / Antígenos Bacterianos Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Europa Idioma: En Revista: Acta Clin Belg Año: 2016 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Reino Unido