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Evidence for a Common Origin of Blacksmiths and Cultivators in the Ethiopian Ari within the Last 4500 Years: Lessons for Clustering-Based Inference.
van Dorp, Lucy; Balding, David; Myers, Simon; Pagani, Luca; Tyler-Smith, Chris; Bekele, Endashaw; Tarekegn, Ayele; Thomas, Mark G; Bradman, Neil; Hellenthal, Garrett.
Afiliación
  • van Dorp L; University College London Genetics Institute (UGI), University College London, London, United Kingdom; Centre for Mathematics and Physics in the Life Sciences and EXperimental Biology (CoMPLEX), University College London, London, United Kingdom.
  • Balding D; University College London Genetics Institute (UGI), University College London, London, United Kingdom; Schools of BioSciences and of Mathematics & Statistics, University of Melbourne, Melbourne, Australia.
  • Myers S; Department of Statistics, University of Oxford, Oxford, United Kingdom.
  • Pagani L; The Wellcome Trust Sanger Institute, Hinxton, United Kingdom; Department of Archaeology and Anthropology, University of Cambridge, Cambridge, United Kingdom.
  • Tyler-Smith C; The Wellcome Trust Sanger Institute, Hinxton, United Kingdom.
  • Bekele E; Addis Ababa University, Addis Ababa, Ethiopia.
  • Tarekegn A; Henry Stewart Group, London, United Kingdom.
  • Thomas MG; Research Department of Genetics, Evolution and Environment, University College London, London, United Kingdom.
  • Bradman N; Henry Stewart Group, London, United Kingdom.
  • Hellenthal G; University College London Genetics Institute (UGI), University College London, London, United Kingdom.
PLoS Genet ; 11(8): e1005397, 2015 Aug.
Article en En | MEDLINE | ID: mdl-26291793
The Ari peoples of Ethiopia are comprised of different occupational groups that can be distinguished genetically, with Ari Cultivators and the socially marginalised Ari Blacksmiths recently shown to have a similar level of genetic differentiation between them (FST ≈ 0.023 - 0.04) as that observed among multiple ethnic groups sampled throughout Ethiopia. Anthropologists have proposed two competing theories to explain the origins of the Ari Blacksmiths as (i) remnants of a population that inhabited Ethiopia prior to the arrival of agriculturists (e.g. Cultivators), or (ii) relatively recently related to the Cultivators but presently marginalized in the community due to their trade. Two recent studies by different groups analysed genome-wide DNA from samples of Ari Blacksmiths and Cultivators and suggested that genetic patterns between the two groups were more consistent with model (i) and subsequent assimilation of the indigenous peoples into the expanding agriculturalist community. We analysed the same samples using approaches designed to attenuate signals of genetic differentiation that are attributable to allelic drift within a population. By doing so, we provide evidence that the genetic differences between Ari Blacksmiths and Cultivators can be entirely explained by bottleneck effects consistent with hypothesis (ii). This finding serves as both a cautionary tale about interpreting results from unsupervised clustering algorithms, and suggests that social constructions are contributing directly to genetic differentiation over a relatively short time period among previously genetically similar groups.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Etnicidad Tipo de estudio: Prognostic_studies Límite: Humans País/Región como asunto: Africa Idioma: En Revista: PLoS Genet Asunto de la revista: GENETICA Año: 2015 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Etnicidad Tipo de estudio: Prognostic_studies Límite: Humans País/Región como asunto: Africa Idioma: En Revista: PLoS Genet Asunto de la revista: GENETICA Año: 2015 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos