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Intestinal Monocyte-Derived Macrophages Control Commensal-Specific Th17 Responses.
Panea, Casandra; Farkas, Adam M; Goto, Yoshiyuki; Abdollahi-Roodsaz, Shahla; Lee, Carolyn; Koscsó, Balázs; Gowda, Kavitha; Hohl, Tobias M; Bogunovic, Milena; Ivanov, Ivaylo I.
Afiliación
  • Panea C; Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
  • Farkas AM; Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
  • Goto Y; Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
  • Abdollahi-Roodsaz S; Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
  • Lee C; Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
  • Koscsó B; Department of Microbiology and Immunology, College of Medicine and Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033, USA.
  • Gowda K; Department of Microbiology and Immunology, College of Medicine and Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033, USA.
  • Hohl TM; Infectious Diseases Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Bogunovic M; Department of Microbiology and Immunology, College of Medicine and Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033, USA.
  • Ivanov II; Department of Microbiology and Immunology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: ii2137@cumc.columbia.edu.
Cell Rep ; 12(8): 1314-24, 2015 Aug 25.
Article en En | MEDLINE | ID: mdl-26279572
Generation of different CD4 T cell responses to commensal and pathogenic bacteria is crucial for maintaining a healthy gut environment, but the associated cellular mechanisms are poorly understood. Dendritic cells (DCs) and macrophages (Mfs) integrate microbial signals and direct adaptive immunity. Although the role of DCs in initiating T cell responses is well appreciated, how Mfs contribute to the generation of CD4 T cell responses to intestinal microbes is unclear. Th17 cells are critical for mucosal immune protection and at steady state are induced by commensal bacteria, such as segmented filamentous bacteria (SFB). Here, we examined the roles of mucosal DCs and Mfs in Th17 induction by SFB in vivo. We show that Mfs, and not conventional CD103(+) DCs, are essential for the generation of SFB-specific Th17 responses. Thus, Mfs drive mucosal T cell responses to certain commensal bacteria.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Th17 / Microbiota / Mucosa Intestinal / Macrófagos Límite: Animals Idioma: En Revista: Cell Rep Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Th17 / Microbiota / Mucosa Intestinal / Macrófagos Límite: Animals Idioma: En Revista: Cell Rep Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos