The interpretation of equivocal or marginal animal carcinogenicity tests.
Cell Biol Toxicol
; 5(4): 371-6, 1989 Dec.
Article
en En
| MEDLINE
| ID: mdl-2627673
The interpretation of animal carcinogenicity tests traditionally rely almost exclusively upon a comparison of specific tumor rates in treated vs. matched and, perhaps, historical control animals. Yet, carcinogenicity tests yield much more biological and pathological data than simply final tumor rates. This additional data should also be considered as part of the total weight of evidence, particularly when analyzing a marginal or equivocal test result. If there are no positive findings among the data discussed here and listed in Table 1, it is unlikely that a marginal or equivocal increase in tumor incidence is actually treatment-related, irrespective of statistical analysis.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pruebas de Carcinogenicidad
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Cell Biol Toxicol
Asunto de la revista:
TOXICOLOGIA
Año:
1989
Tipo del documento:
Article
Pais de publicación:
Suiza