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The relation of the number of hydrogen-bond acceptors with recoveries of immunosuppressants in DBS analysis.
Koster, Remco A; Alffenaar, Jan-Willem C; Botma, Rixt; Greijdanus, Ben; Uges, Donald Ra; Kosterink, Jos Gw; Touw, Daan J.
Afiliación
  • Koster RA; University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy & Pharmacology, Clinical Pharmaceutical & Toxicological Laboratory, PO Box 30.001, 9700 RB, Groningen, The Netherlands.
  • Alffenaar JW; University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy & Pharmacology, Clinical Pharmaceutical & Toxicological Laboratory, PO Box 30.001, 9700 RB, Groningen, The Netherlands.
  • Botma R; University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy & Pharmacology, Clinical Pharmaceutical & Toxicological Laboratory, PO Box 30.001, 9700 RB, Groningen, The Netherlands.
  • Greijdanus B; University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy & Pharmacology, Clinical Pharmaceutical & Toxicological Laboratory, PO Box 30.001, 9700 RB, Groningen, The Netherlands.
  • Uges DR; University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy & Pharmacology, Clinical Pharmaceutical & Toxicological Laboratory, PO Box 30.001, 9700 RB, Groningen, The Netherlands.
  • Kosterink JG; University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy & Pharmacology, Clinical Pharmaceutical & Toxicological Laboratory, PO Box 30.001, 9700 RB, Groningen, The Netherlands.
  • Touw DJ; University of Groningen, Department of Pharmacy, Section Pharmacotherapy & Pharmaceutical Care, Groningen, The Netherlands.
Bioanalysis ; 7(14): 1717-22, 2015.
Article en En | MEDLINE | ID: mdl-26270779
BACKGROUND: We investigated the influence of the number of hydrogen-bond acceptors on the recovery of immunosuppressant drugs and their structural analogs. This hypothesis was tested by evaluation of the extraction recoveries of tacrolimus, ascomycin, sirolimus, everolimus and temsirolimus with 12, 12, 13, 14 and 16 hydrogen-bond acceptors, respectively. RESULTS: With an increasing number of hydrogen-bond acceptors of sirolimus, everolimus and temsirolimus, a decrease in recoveries was found while ascomycin showed recoveries corresponding to those of tacrolimus. CONCLUSION: This study showed that the number of hydrogen-bond acceptors of the analyte of interest may influence the recoveries in dried blood spot analysis and is a relevant factor to be investigated during method development and validation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas con Sangre Seca / Enlace de Hidrógeno / Inmunosupresores Límite: Humans Idioma: En Revista: Bioanalysis Año: 2015 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pruebas con Sangre Seca / Enlace de Hidrógeno / Inmunosupresores Límite: Humans Idioma: En Revista: Bioanalysis Año: 2015 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Reino Unido