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Sedative and cardiopulmonary effects of xylazine alone or in combination with methadone, morphine or tramadol in sheep.
de Carvalho, Leonardo L; Nishimura, Lilian T; Borges, Luisa P B; Cerejo, Sofia A; Villela, Isadora O J; Auckburally, Adam; de Mattos-Junior, Ewaldo.
Afiliación
  • de Carvalho LL; School of Veterinary Medicine, University of Franca, Franca, SP, Brazil.
  • Nishimura LT; School of Veterinary Medicine, University of Franca, Franca, SP, Brazil.
  • Borges LP; School of Veterinary Medicine, University of Franca, Franca, SP, Brazil.
  • Cerejo SA; School of Veterinary Medicine and Animal Science, São Paulo State University (Universidade Estadual Paulista, UNESP) Botucatu, Botucatu, SP, Brazil.
  • Villela IO; School of Veterinary Medicine, University of Franca, Franca, SP, Brazil.
  • Auckburally A; Department of Small Animal Clinical Sciences, School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
  • de Mattos-Junior E; School of Veterinary Medicine, University of Franca, Franca, SP, Brazil.
Vet Anaesth Analg ; 43(2): 179-88, 2016 Mar.
Article en En | MEDLINE | ID: mdl-26267292
OBJECTIVE: To evaluate the cardiopulmonary and sedative effects of xylazine alone or in combination with methadone, morphine or tramadol in sheep. STUDY DESIGN: Experimental, prospective, crossover, randomized, blinded study. ANIMALS: Six Santa Inês breed sheep (females) aged 12 ± 8 months and weighing 39.5 ± 7.4 kg. METHODS: Sheep were sedated with each of four treatments in a randomized, crossover design, with a minimum washout period of 7 days between treatments. Treatments were: X [xylazine (0.1 mg kg(-1))]; XM [xylazine (0.1 mg kg(-1)) and methadone (0.5 mg kg(-1))]; XMO [xylazine (0.1 mg kg(-1)) and morphine (0.5 mg kg(-1))], and XT [xylazine (0.1 mg kg(-1)) and tramadol (5 mg kg(-1))]. Each drug combination was mixed in the syringe and injected intravenously. Sedation, heart rate (HR), mean arterial blood pressure (MAP), rectal temperature (RT°C), respiratory rate (fR), arterial blood gases and electrolytes were measured before drug administration (T0) and then at 15 minute intervals for 120 minutes (T15-T120). RESULTS: Heart rate significantly decreased in all treatments compared with T0. PaCO2 values in XM and XMO were higher at all time points compared with T0. In treatments X and XM, pH, bicarbonate (HCO3-) and base excess were increased at all time points compared with T0. PaO2 was significantly decreased at T15-T75 in XM, at all time points in XMO, and at T15 and T30 in XT. Sedation at T15 and T30 in XM and XMO was greater than in the other treatments. CONCLUSIONS AND CLINICAL RELEVANCE: The combinations of methadone, morphine or tramadol with xylazine resulted in cardiopulmonary changes similar to those induced by xylazine alone in sheep. The combinations provided better sedation, principally at 15 minutes and 30 minutes following administration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Respiratorio / Tramadol / Xilazina / Sistema Cardiovascular / Hipnóticos y Sedantes / Metadona / Morfina Tipo de estudio: Observational_studies Límite: Animals Idioma: En Revista: Vet Anaesth Analg Asunto de la revista: ANESTESIOLOGIA / MEDICINA VETERINARIA Año: 2016 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sistema Respiratorio / Tramadol / Xilazina / Sistema Cardiovascular / Hipnóticos y Sedantes / Metadona / Morfina Tipo de estudio: Observational_studies Límite: Animals Idioma: En Revista: Vet Anaesth Analg Asunto de la revista: ANESTESIOLOGIA / MEDICINA VETERINARIA Año: 2016 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Estados Unidos