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Development of an in vivo tissue-engineered vascular graft with designed wall thickness (biotube type C) based on a novel caged mold.
Furukoshi, Maya; Moriwaki, Takeshi; Nakayama, Yasuhide.
Afiliación
  • Furukoshi M; Division of Medical Engineering and Materials, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
  • Moriwaki T; Division of Medical Engineering and Materials, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan.
  • Nakayama Y; Division of Medical Engineering and Materials, National Cerebral and Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka, 565-8565, Japan. ny@ncvc.go.jp.
J Artif Organs ; 19(1): 54-61, 2016 Mar.
Article en En | MEDLINE | ID: mdl-26265146
Small-diameter biotube vascular grafts developed by in-body tissue architecture had high patency at implantation into rabbit carotid arteries or rat abdominal aortas. However, the thin walls (34 ± 14 µm) of the original biotubes made their implantation difficult into areas with low blood flow volumes or low blood pressure due to insufficient mechanical strength to maintain luminal shape. In this study, caged molds with several windows were designed to prepare more robust biotubes. The molds were assembled with silicone tubes (external diameter 2 mm) and cylindrical covers (outer diameter 7 mm) with 12 linear windows (1 × 9 mm). After the molds were embedded into beagle dorsal subcutaneous pouches for 4 weeks, type C (cage) biotubes were obtained by completely extracting the surrounding connective tissues from the molds and removing the molds. The biotube walls (778 ± 31 µm) were formed at the aperture (width 1 mm) between the silicone rods and the covers by connective cell migration through the windows of the covers. Excellent mechanical properties (external pressure resistance, approximately 4 times higher than beagle native femoral arteries; burst strength, approximately 2 times higher than original biotubes) were obtained. In the acute phase of implantation of the biotubes into beagle femoral arteries, perfect patency was obtained with little stenosis and no aneurysmal dilation. The type C biotubes may be useful for implantation into peripheral arteries or veins in addition to aortas.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bioprótesis / Prótesis Vascular / Ingeniería de Tejidos / Injerto Vascular Límite: Animals Idioma: En Revista: J Artif Organs Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2016 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bioprótesis / Prótesis Vascular / Ingeniería de Tejidos / Injerto Vascular Límite: Animals Idioma: En Revista: J Artif Organs Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2016 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón