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Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor.
Stahl, Sebastian; da Silva Mateus Seidl, Ana Rita; Ducret, Axel; Kux van Geijtenbeek, Sabine; Michel, Sven; Racek, Tomas; Birzele, Fabian; Haas, Alexander K; Rueger, Ruediger; Gerg, Michael; Niederfellner, Gerhard; Pastan, Ira; Brinkmann, Ulrich.
Afiliación
  • Stahl S; Roche Pharma Research & Early Development, Large Molecule Research, Roche Innovation Center Penzberg, 82377 Penzberg, Germany;
  • da Silva Mateus Seidl AR; Roche Pharma Research & Early Development, Discovery Oncology, Roche Innovation Center Penzberg, 82377 Penzberg, Germany;
  • Ducret A; Roche Pharma Research & Early Development, Pharmaceutical Sciences, Translational Technology and Bioinformatics, Roche Innovation Center Basel, 4070 Basel, Switzerland;
  • Kux van Geijtenbeek S; Roche Pharma Research & Early Development, Pharmaceutical Sciences, Translational Technology and Bioinformatics, Roche Innovation Center Basel, 4070 Basel, Switzerland;
  • Michel S; Roche Pharma Research & Early Development, Pharmaceutical Sciences, Translational Technology and Bioinformatics, Roche Innovation Center Basel, 4070 Basel, Switzerland;
  • Racek T; Roche Pharma Research & Early Development, Pharmaceutical Sciences, Translational Technology and Bioinformatics, Roche Innovation Center Penzberg, 82377 Penzberg, Germany;
  • Birzele F; Roche Pharma Research & Early Development, Pharmaceutical Sciences, Translational Technology and Bioinformatics, Roche Innovation Center Penzberg, 82377 Penzberg, Germany;
  • Haas AK; Roche Pharma Research & Early Development, Large Molecule Research, Roche Innovation Center Penzberg, 82377 Penzberg, Germany;
  • Rueger R; Roche Pharma Research & Early Development, Pharmaceutical Sciences, Translational Technology and Bioinformatics, Roche Innovation Center Penzberg, 82377 Penzberg, Germany;
  • Gerg M; Roche Diagnostics, Roche Professional Diagnostics, Biological Rare Reagents, 82377 Penzberg, Germany;
  • Niederfellner G; Roche Pharma Research & Early Development, Discovery Oncology, Roche Innovation Center Penzberg, 82377 Penzberg, Germany;
  • Pastan I; Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda MD 20892-4263 pastani@mail.nih.gov ulrich.brinkmann@roche.com.
  • Brinkmann U; Roche Pharma Research & Early Development, Large Molecule Research, Roche Innovation Center Penzberg, 82377 Penzberg, Germany; pastani@mail.nih.gov ulrich.brinkmann@roche.com.
Proc Natl Acad Sci U S A ; 112(34): 10732-7, 2015 Aug 25.
Article en En | MEDLINE | ID: mdl-26261303
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: FN-kappa B / Apoptosis / Factor 2 de Elongación Peptídica / Receptores de Muerte Celular / Histidina Límite: Female / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: FN-kappa B / Apoptosis / Factor 2 de Elongación Peptídica / Receptores de Muerte Celular / Histidina Límite: Female / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos