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Molecular and clinical diseasome of comorbidities in exacerbated COPD patients.
Faner, Rosa; Gutiérrez-Sacristán, Alba; Castro-Acosta, Ady; Grosdidier, Solène; Gan, Wenqi; Sánchez-Mayor, Milagros; Lopez-Campos, Jose Luis; Pozo-Rodriguez, Francisco; Sanz, Ferran; Mannino, David; Furlong, Laura I; Agusti, Alvar.
Afiliación
  • Faner R; Fundació Privada Clinic per a la Recerca Biomèdica, Barcelona, Spain CIBER Enfermedades Respiratorias (CIBERES), Spain Co-primary authors.
  • Gutiérrez-Sacristán A; Integrative Biomedical Informatics Group, Research Program on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM), Universitat Pompeu Fabra, Barcelona, Spain Co-primary authors.
  • Castro-Acosta A; CIBER Enfermedades Respiratorias (CIBERES), Spain Instituto de Investigación, Hospital 12 de Octubre, Madrid, Spain.
  • Grosdidier S; Integrative Biomedical Informatics Group, Research Program on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM), Universitat Pompeu Fabra, Barcelona, Spain.
  • Gan W; Dept of Preventive Medicine and Environmental Health, University of Kentucky College of Public Health, Lexington, KY, USA.
  • Sánchez-Mayor M; Integrative Biomedical Informatics Group, Research Program on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM), Universitat Pompeu Fabra, Barcelona, Spain.
  • Lopez-Campos JL; CIBER Enfermedades Respiratorias (CIBERES), Spain Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocio/Universidad de Sevilla, Sevilla, Spain.
  • Pozo-Rodriguez F; CIBER Enfermedades Respiratorias (CIBERES), Spain Instituto de Investigación, Hospital 12 de Octubre, Madrid, Spain.
  • Sanz F; Integrative Biomedical Informatics Group, Research Program on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM), Universitat Pompeu Fabra, Barcelona, Spain.
  • Mannino D; Dept of Preventive Medicine and Environmental Health, University of Kentucky College of Public Health, Lexington, KY, USA.
  • Furlong LI; Integrative Biomedical Informatics Group, Research Program on Biomedical Informatics (GRIB), Hospital del Mar Medical Research Institute (IMIM), Universitat Pompeu Fabra, Barcelona, Spain.
  • Agusti A; Fundació Privada Clinic per a la Recerca Biomèdica, Barcelona, Spain CIBER Enfermedades Respiratorias (CIBERES), Spain Thorax Institute, Hospital Clinic, IDIBAPS, Univ. Barcelona, Barcelona, Spain alvar.agusti@clinic.ub.es.
Eur Respir J ; 46(4): 1001-10, 2015 Oct.
Article en En | MEDLINE | ID: mdl-26250499
The frequent occurrence of comorbidities in patients with chronic obstructive pulmonary disease (COPD) suggests that they may share pathobiological processes and/or risk factors.To explore these possibilities we compared the clinical diseasome and the molecular diseasome of 5447 COPD patients hospitalised because of an exacerbation of the disease. The clinical diseasome is a network representation of the relationships between diseases, in which diseases are connected if they co-occur more than expected at random; in the molecular diseasome, diseases are linked if they share associated genes or interaction between proteins.The results showed that about half of the disease pairs identified in the clinical diseasome had a biological counterpart in the molecular diseasome, particularly those related to inflammation and vascular tone regulation. Interestingly, the clinical diseasome of these patients appears independent of age, cumulative smoking exposure or severity of airflow limitation.These results support the existence of shared molecular mechanisms among comorbidities in COPD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Comorbilidad / Enfermedad Pulmonar Obstructiva Crónica Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Eur Respir J Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Comorbilidad / Enfermedad Pulmonar Obstructiva Crónica Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Eur Respir J Año: 2015 Tipo del documento: Article Pais de publicación: Reino Unido