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Association between Low-density Lipoprotein Receptor-related Protein 5 Polymorphisms and Type 2 Diabetes Mellitus in Han Chinese: a Case-control Study.
You, Hai Fei; Zhao, Jing Zhi; Zhai, Yu Jia; Yin, Lei; Pang, Chao; Luo, Xin Ping; Zhang, Ming; Wang, Jin Jin; Li, Lin Lin; Wang, Yan; Wang, Qian; Wang, Bing Yuan; Ren, Yong Cheng; Hu, Dong Sheng.
Afiliación
  • You HF; Department of Blood Transfusion, Xijing Hospital, The Fourth Military Medical University, Xi'an 710023, Shannxi, China; Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
  • Zhao JZ; Military Hospital of Henan Province, Zhengzhou 450003, Henan, China.
  • Zhai YJ; Department of Public Health Surveillance & Advisory, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, Zhejiang, China.
  • Yin L; Military Hospital of Henan Province, Zhengzhou 450003, Henan, China.
  • Pang C; Military Hospital of Henan Province, Zhengzhou 450003, Henan, China.
  • Luo XP; Shenzhen University School of Medicine, Shenzhen 518060, Guangdong, China.
  • Zhang M; Shenzhen University School of Medicine, Shenzhen 518060, Guangdong, China.
  • Wang JJ; Discipline of Public Health and Preventive Medicine, Center of Preventive Medicine Research and Assessment, Henan University of Traditional Chinese Medicine, Zhengzhou 450008, Henan, China.
  • Li LL; Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
  • Wang Y; Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
  • Wang Q; Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
  • Wang BY; Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
  • Ren YC; Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China.
  • Hu DS; Shenzhen University School of Medicine, Shenzhen 518060, Guangdong, China.
Biomed Environ Sci ; 28(7): 510-7, 2015 Jul.
Article en En | MEDLINE | ID: mdl-26248735
OBJECTIVE: To investigate the association between low-density lipoprotein receptor-related protein 5 (LRP5) variants (rs12363572 and rs4930588) and type 2 diabetes mellitus (T2DM) in Han Chinese. METHODS: A total of 1842 T2DM cases (507 newly diagnosed cases and 1335 previously diagnosed cases) and 7777 controls were included in this case-control study. PCR-RFLP was conducted to detect the genotype of the two single nucleotide polymorphisms (SNPs). Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to describe the strength of the association by logistic regression. RESULTS: In the study subjects, neither rs12363572 nor rs4930588 was significantly associated with T2DM, even after adjusting for relevant covariates. When stratified by body mass index (BMI), the two SNPs were also not associated with T2DM. Among the 3 common haplotypes, only haplotype TT was associated with reduced risk of T2DM (OR 0.820, 95% CI 0.732-0.919). In addition, rs12363572 was associated with BMI (P<0.001) and rs4930588 was associated with triglyceride levels (P=0.043) in 507 newly diagnosed T2DM cases but not in healthy controls. CONCLUSION: No LRP5 variant was found to be associated with T2DM in Han Chinese, but haplotype TT was found to be associated with T2DM.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo de Nucleótido Simple / Pueblo Asiatico / Diabetes Mellitus Tipo 2 / Proteína-5 Relacionada con Receptor de Lipoproteína de Baja Densidad Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Biomed Environ Sci Asunto de la revista: SAUDE AMBIENTAL Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: China
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polimorfismo de Nucleótido Simple / Pueblo Asiatico / Diabetes Mellitus Tipo 2 / Proteína-5 Relacionada con Receptor de Lipoproteína de Baja Densidad Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged Idioma: En Revista: Biomed Environ Sci Asunto de la revista: SAUDE AMBIENTAL Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: China