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Red Blood Cell Docosapentaenoic Acid (DPA n-3) is Inversely Associated with Triglycerides and C-reactive Protein (CRP) in Healthy Adults and Dose-Dependently Increases Following n-3 Fatty Acid Supplementation.
Skulas-Ray, Ann C; Flock, Michael R; Richter, Chesney K; Harris, William S; West, Sheila G; Kris-Etherton, Penny M.
Afiliación
  • Skulas-Ray AC; Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA. aus164@psu.edu.
  • Flock MR; Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA. mike.flock@gmail.com.
  • Richter CK; Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA. ckr129@psu.edu.
  • Harris WS; OmegaQuant Analytics, LLC, Sioux Falls, SD 57106, USA. Bill@omegaquant.com.
  • West SG; Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA. sgw2@psu.edu.
  • Kris-Etherton PM; Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16802, USA. sgw2@psu.edu.
Nutrients ; 7(8): 6390-404, 2015 Aug 04.
Article en En | MEDLINE | ID: mdl-26247967
The role of the long-chain omega-3 (n-3) fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in lipid metabolism and inflammation has been extensively studied; however, little is known about the relationship between docosapentaenoic acid (DPA, 22:5 n-3) and inflammation and triglycerides (TG). We evaluated whether n-3 DPA content of red blood cells (RBC) was associated with markers of inflammation (interleukin-6 (IL-6), tumor necrosis factor α (TNF-α), and C-reactive protein (CRP) and fasting TG prior to n-3 supplementation in two studies (Study 1: n = 115, aged 20-44 years, body mass index (BMI) 20-30 kg/m2, TG = 34-176 mg/dL; Study 2: n = 28, aged 22-65 years, BMI 24-37 kg/m2, TG = 141-339 mg/dL). We also characterized the dose-response effects of n-3 fatty acid supplementation on RBC n-3 DPA after five months of supplementation with fish oil (Study 1: 0, 300, 600, 900, and 1800 mg/day EPA + DHA) and eight weeks of prescription n-3 ethyl esters (Study 2: 0, 850, and 3400 mg/day EPA + DHA). In Study 1, RBC n-3 DPA was inversely correlated with CRP (R2 = 36%, p < 0.001) and with fasting TG (r = -0.30, p = 0.001). The latter finding was replicated in Study 2 (r = -0.33, p = 0.04). In both studies, n-3 supplementation significantly increased RBC n-3 DPA dose-dependently. Relative increases were greater for Study 1, with increases of 29%-61% vs. 14%-26% for Study 2. The associations between RBC n-3 DPA, CRP, and fasting TG may have important implications for the prevention of atherosclerosis and chronic inflammatory diseases and warrant further study.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triglicéridos / Proteína C-Reactiva / Ácidos Grasos Omega-3 / Eritrocitos / Ácidos Grasos Insaturados Tipo de estudio: Clinical_trials / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nutrients Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Triglicéridos / Proteína C-Reactiva / Ácidos Grasos Omega-3 / Eritrocitos / Ácidos Grasos Insaturados Tipo de estudio: Clinical_trials / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nutrients Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza