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Selective Serotonin Reuptake Inhibitors Plus Phosphodiesterase-5 Inhibitors for Premature Ejaculation: A Systematic Review and Meta-analysis.
Bai, Yunjin; Pu, Chunxiao; Han, Ping; Li, Jinhong; Yuan, Haichao; Tang, Yin; Wang, Xiaoming; Wei, Qiang.
Afiliación
  • Bai Y; Department of Urology, West China Hospital, Sichuan University, Chengdu, China.
  • Pu C; Department of Urology, West China Hospital, Sichuan University, Chengdu, China.
  • Han P; Department of Urology, West China Hospital, Sichuan University, Chengdu, China. Electronic address: hanpinghxyy@163.com.
  • Li J; Department of Urology, West China Hospital, Sichuan University, Chengdu, China.
  • Yuan H; Department of Urology, West China Hospital, Sichuan University, Chengdu, China; Department of Urology, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China.
  • Tang Y; Department of Urology, West China Hospital, Sichuan University, Chengdu, China.
  • Wang X; Department of Urology, West China Hospital, Sichuan University, Chengdu, China.
  • Wei Q; Department of Urology, West China Hospital, Sichuan University, Chengdu, China.
Urology ; 86(4): 758-64, 2015 Oct.
Article en En | MEDLINE | ID: mdl-26247816
OBJECTIVE: To evaluate the efficacy and safety of combination therapy with selective serotonin reuptake inhibitors (SSRIs) and phosphodiesterase-5 (PDE-5) inhibitors for the treatment of premature ejaculation (PE). METHODS: A systematic search of EMBASE, MEDLINE, the Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews was undertaken to identify articles that referred to the use of a combination of SSRIs and PDE-5 inhibitors for the treatment of PE. A meta-analysis of these clinical studies was performed. The post-treatment intravaginal ejaculatory latency time (IELT) and adverse events (AEs) were used in this meta-analysis. RESULTS: Six publications involving 971 patients were included in the meta-analysis. In the analysis, we found significantly improved IELT in the combination use group compared with the use of SSRIs (mean differences [MD], 1.01; 95% confidence interval [CI], 0.61-1.41; P <.01) or PDE-5 inhibitors alone (MD, 1.11; 95% CI, 0.79-1.43; P <.01) for PE whether or not these patients suffered from erectile dysfunction. Combined treatment was more efficacious than use of PDE-5 inhibitors alone on sexual satisfaction. Although the occurrence of drug-related AEs in the combination use group was higher than that in the use of SSRIs or PDE-5 inhibitors alone group (37.5% vs 25.63%, P <.01), the most common AEs were mild and tolerable. CONCLUSION: The combined use of SSRIs and PDE-5 inhibitors provided additive favorable effects in men with PE compared with SSRIs or PDE-5 inhibitors monotherapy and was generally well tolerated.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores Selectivos de la Recaptación de Serotonina / Eyaculación / Fosfodiesterasas de Nucleótidos Cíclicos Tipo 5 / Eyaculación Prematura Tipo de estudio: Systematic_reviews Límite: Humans / Male Idioma: En Revista: Urology Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores Selectivos de la Recaptación de Serotonina / Eyaculación / Fosfodiesterasas de Nucleótidos Cíclicos Tipo 5 / Eyaculación Prematura Tipo de estudio: Systematic_reviews Límite: Humans / Male Idioma: En Revista: Urology Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos