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Outcome of second- and third-line Helicobacter pylori eradication therapies based on antimicrobial susceptibility testing.
Draeger, Sarah; Wüppenhorst, Nicole; Kist, Manfred; Glocker, Erik-Oliver.
Afiliación
  • Draeger S; National Reference Centre for Helicobacter pylori, Department of Medical Microbiology and Hygiene, Institute of Medical Microbiology and Hygiene, University Medical Centre Freiburg, Hermann-Herder-Straße 11, 79104 Freiburg, Germany.
  • Wüppenhorst N; National Reference Centre for Helicobacter pylori, Department of Medical Microbiology and Hygiene, Institute of Medical Microbiology and Hygiene, University Medical Centre Freiburg, Hermann-Herder-Straße 11, 79104 Freiburg, Germany.
  • Kist M; National Reference Centre for Helicobacter pylori, Department of Medical Microbiology and Hygiene, Institute of Medical Microbiology and Hygiene, University Medical Centre Freiburg, Hermann-Herder-Straße 11, 79104 Freiburg, Germany.
  • Glocker EO; National Reference Centre for Helicobacter pylori, Department of Medical Microbiology and Hygiene, Institute of Medical Microbiology and Hygiene, University Medical Centre Freiburg, Hermann-Herder-Straße 11, 79104 Freiburg, Germany erik-oliver.glocker@uniklinik-freiburg.de.
J Antimicrob Chemother ; 70(11): 3141-5, 2015 Nov.
Article en En | MEDLINE | ID: mdl-26245638
OBJECTIVES: The objective of this study was to assess the outcome of antimicrobial susceptibility-guided therapies in Helicobacter pylori-infected individuals who had undergone unsuccessful prior eradication treatments. METHODS: From October 2004 to December 2013, 481 H. pylori-positive patients with prior unsuccessful eradication treatments were administered susceptibility-guided salvage eradication treatments. Six months on, treatment outcome was assessed by urea breath test, stool antigen ELISA, Helicobacter urease test or microbiology and/or histopathology. RESULTS: Resistance to metronidazole and clarithromycin was high in patients with prior unsuccessful eradication treatments and was dependent on the number of treatment failures. Susceptibility-guided salvage eradication treatments achieved eradication rates of nearly 70% in these patients. No particular regimen was significantly better than another. CONCLUSIONS: Antimicrobial susceptibility testing prevents prescription of inefficient antimicrobials and enables individualized and promising salvage treatments in patients with prior unsuccessful eradication treatments.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Helicobacter pylori / Infecciones por Helicobacter / Terapia Recuperativa / Antibacterianos Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: J Antimicrob Chemother Año: 2015 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Helicobacter pylori / Infecciones por Helicobacter / Terapia Recuperativa / Antibacterianos Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Female / Humans / Male Idioma: En Revista: J Antimicrob Chemother Año: 2015 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido