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The function and affinity maturation of HIV-1 gp120-specific monoclonal antibodies derived from colostral B cells.
Jeffries, T L; Sacha, C R; Pollara, J; Himes, J; Jaeger, F H; Dennison, S M; McGuire, E; Kunz, E; Eudailey, J A; Trama, A M; LaBranche, C; Fouda, G G; Wiehe, K; Montefiori, D C; Haynes, B F; Liao, H-X; Ferrari, G; Alam, S M; Moody, M A; Permar, S R.
Afiliación
  • Jeffries TL; Duke University Medical Center, Duke Human Vaccine Institute, Durham, North Carolina, USA.
  • Sacha CR; Duke University Medical Center, Duke Human Vaccine Institute, Durham, North Carolina, USA.
  • Pollara J; Duke University Medical Center, Duke Human Vaccine Institute, Durham, North Carolina, USA.
  • Himes J; Duke University Medical Center, Duke Human Vaccine Institute, Durham, North Carolina, USA.
  • Jaeger FH; Duke University Medical Center, Duke Human Vaccine Institute, Durham, North Carolina, USA.
  • Dennison SM; Duke University Medical Center, Duke Human Vaccine Institute, Durham, North Carolina, USA.
  • McGuire E; Duke University Medical Center, Duke Human Vaccine Institute, Durham, North Carolina, USA.
  • Kunz E; Duke University Medical Center, Duke Human Vaccine Institute, Durham, North Carolina, USA.
  • Eudailey JA; Duke University Medical Center, Duke Human Vaccine Institute, Durham, North Carolina, USA.
  • Trama AM; Duke University Medical Center, Duke Human Vaccine Institute, Durham, North Carolina, USA.
  • LaBranche C; Duke University Medical Center, Duke Human Vaccine Institute, Durham, North Carolina, USA.
  • Fouda GG; Duke University Medical Center, Duke Human Vaccine Institute, Durham, North Carolina, USA.
  • Wiehe K; Duke University Medical Center, Duke Human Vaccine Institute, Durham, North Carolina, USA.
  • Montefiori DC; Duke University Medical Center, Duke Human Vaccine Institute, Durham, North Carolina, USA.
  • Haynes BF; Duke University Medical Center, Duke Human Vaccine Institute, Durham, North Carolina, USA.
  • Liao HX; Duke University Medical Center, Duke Human Vaccine Institute, Durham, North Carolina, USA.
  • Ferrari G; Department of Surgery, Duke University, Durham, North Carolina, USA.
  • Alam SM; Duke University Medical Center, Duke Human Vaccine Institute, Durham, North Carolina, USA.
  • Moody MA; Duke University Medical Center, Duke Human Vaccine Institute, Durham, North Carolina, USA.
  • Permar SR; Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA.
Mucosal Immunol ; 9(2): 414-27, 2016 Mar.
Article en En | MEDLINE | ID: mdl-26242599
Despite the risk of transmitting HIV-1, mothers in resource-poor areas are encouraged to breastfeed their infants because of beneficial immunologic and nutritional factors in milk. Interestingly, in the absence of antiretroviral prophylaxis, the overwhelming majority of HIV-1-exposed, breastfeeding infants are naturally protected from infection. To understand the role of HIV-1 envelope (Env)-specific antibodies in breast milk in natural protection against infant virus transmission, we produced 19 HIV-1 Env-specific monoclonal antibodies (mAbs) isolated from colostrum B cells of HIV-1-infected mothers and investigated their specificity, evolution, and anti-HIV-1 functions. Despite the previously reported genetic compartmentalization and gp120-specific bias of colostrum HIV Env-specific B cells, the colostrum Env-specific mAbs described here demonstrated a broad range of gp120 epitope specificities and functions, including inhibition of epithelial cell binding and dendritic cell-mediated virus transfer, neutralization, and antibody-dependent cellular cytotoxicity. We also identified divergent patterns of colostrum Env-specific B-cell lineage evolution with respect to crossreactivity to gastrointestinal commensal bacteria, indicating that commensal bacterial antigens play a role in shaping the local breast milk immunoglobulin G (IgG) repertoire. Maternal vaccine strategies to specifically target this breast milk B-cell population may be necessary to achieve safe breastfeeding for all HIV-1-exposed infants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoglobulina G / Linfocitos B / Anticuerpos Anti-VIH / Proteína gp120 de Envoltorio del VIH / Calostro / Anticuerpos Neutralizantes / Anticuerpos Monoclonales Tipo de estudio: Prognostic_studies Idioma: En Revista: Mucosal Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inmunoglobulina G / Linfocitos B / Anticuerpos Anti-VIH / Proteína gp120 de Envoltorio del VIH / Calostro / Anticuerpos Neutralizantes / Anticuerpos Monoclonales Tipo de estudio: Prognostic_studies Idioma: En Revista: Mucosal Immunol Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos