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Neurological and cerebellar soft signs do not discriminate schizophrenia from bipolar disorder patients.
Chrobak, Adrian Andrzej; Siwek, Grzegorz Przemyslaw; Siuda-Krzywicka, Katarzyna; Arciszewska, Aleksandra; Starowicz-Filip, Anna; Siwek, Marcin; Dudek, Dominika.
Afiliación
  • Chrobak AA; Faculty of Medicine, Jagiellonian University Medical College, Kopernika St. 21A, Cracow 31-501, Poland. Electronic address: adrian.andrzej.chrobak@gmail.com.
  • Siwek GP; Faculty of Medicine, Jagiellonian University Medical College, Kopernika St. 21A, Cracow 31-501, Poland.
  • Siuda-Krzywicka K; Department of Psychophysiology, Faculty of Psychology, Jagiellonian University, Ingardena St. 6, Cracow 30-060, Poland; École des Neurosciences à Paris, France.
  • Arciszewska A; Department of Affective Disorders, Chair of Psychiatry, Jagiellonian University Medical College, Kopernika St. 21A, Cracow 31-501, Poland.
  • Starowicz-Filip A; Medical Psychology Department, Jagiellonian University Medical College, Kopernika St. 21A, Cracow 31-501, Poland.
  • Siwek M; Department of Affective Disorders, Chair of Psychiatry, Jagiellonian University Medical College, Kopernika St. 21A, Cracow 31-501, Poland.
  • Dudek D; Department of Affective Disorders, Chair of Psychiatry, Jagiellonian University Medical College, Kopernika St. 21A, Cracow 31-501, Poland.
Prog Neuropsychopharmacol Biol Psychiatry ; 64: 96-101, 2016 Jan 04.
Article en En | MEDLINE | ID: mdl-26241859
Patients with schizophrenia (SZ) and bipolar disorder (BD) share subtle motor abnormalities called the neurological soft signs (NSS). Since in both diseases there is evidence for alterations in cerebellar functions, structure and connectivity, we expected that the cerebellar soft signs (CSS), analogue of NSS focusing strictly on cerebellar symptoms, would be also a common trait in SZ and BD. We examined 30 patients with BD, 30 patients with SZ and 28 control subjects using the Neurological Evaluation Scale (NES, for NSS) and International Cooperative Ataxia Rating Scale (ICARS, for CSS). SZ and BD did not differ in total and subscales' scores in both NES and ICARS. Subscale analysis revealed that SZ performed significantly worse than controls in all the subscales of both NES and ICARS. BD patients scored significantly worse than controls in all NES subscales and in oculomotor and kinetic subscales of the ICARS, while other ICARS subscales did not differentiate those two groups. To our knowledge this is the first study to show that CSS constitute common symptoms in BD and SZ. We recommend a special focus on those diseases in further research regarding structural and functional changes of cerebellum and their clinical outcome.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Trastorno Bipolar / Cerebelo / Actividad Motora Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Esquizofrenia / Trastorno Bipolar / Cerebelo / Actividad Motora Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Año: 2016 Tipo del documento: Article Pais de publicación: Reino Unido