Design, development, drug-likeness, and molecular docking studies of novel piperidin-4-imine derivatives as antitubercular agents.

Revathi, Rajappan; Venkatesha Perumal, Ramachandran; Pai, Karkala Sreedhara Ranganath; Arunkumar, Govindakarnavar; Sriram, Dharmarajan; Kini, Suvarna Ganesh

Revathi, Rajappan; Venkatesha Perumal, Ramachandran; Pai, Karkala Sreedhara Ranganath; Arunkumar, Govindakarnavar; Sriram, Dharmarajan; Kini, Suvarna Ganesh.

Afiliación

Revathi R; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, India.
Venkatesha Perumal R; Bharathi College of Pharmacy, Bharathi Nagara, Karnataka, India.
Pai KS; Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, India.
Arunkumar G; Manipal Centre of Virus Research, Manipal University, Manipal, Karnataka, India.
Sriram D; Pharmacy Group, Birla Institute of Technology and Science-Pilani, Hyderabad Campus, Hyderabad, India.
Kini SG; Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka, India.

Drug Des Devel Ther ; 9: 3779-87, 2015.

Article en En | MEDLINE | ID: mdl-26229439

Asunto(s)

Antituberculosos/farmacología; Iminas/farmacología; Mycobacterium tuberculosis/efectos de los fármacos; Piperidinas/farmacología; Animales; Antituberculosos/síntesis química; Antituberculosos/química; Chlorocebus aethiops; Diseño de Fármacos; Iminas/síntesis química; Iminas/química; Pruebas de Sensibilidad Microbiana; Simulación del Acoplamiento Molecular; Piperidinas/síntesis química; Piperidinas/química; Células Vero

Palabras clave

Mycobacterium tuberculosis; Schiff's reaction; benzimidazole; enoyl-acyl carrier protein reductase

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperidinas / Iminas / Mycobacterium tuberculosis / Antituberculosos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Drug Des Devel Ther Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2015 Tipo del documento: Article País de afiliación: India Pais de publicación: Nueva Zelanda

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