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Altered threat and safety neural processing linked to persecutory delusions in schizophrenia: a two-task fMRI study.
Perez, David L; Pan, Hong; Weisholtz, Daniel S; Root, James C; Tuescher, Oliver; Fischer, David B; Butler, Tracy; Vago, David R; Isenberg, Nancy; Epstein, Jane; Landa, Yulia; Smith, Thomas E; Savitz, Adam J; Silbersweig, David A; Stern, Emily.
Afiliación
  • Perez DL; Functional Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Department of Psychiatry, 824 Boylston Street, Chestnut Hill, MA 02467, USA.
  • Pan H; Functional Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Department of Psychiatry, 824 Boylston Street, Chestnut Hill, MA 02467, USA; Brigham and Women's Hospital, Department of Radiology, Harvard Medical School, Boston, MA, USA.
  • Weisholtz DS; Functional Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Department of Psychiatry, 824 Boylston Street, Chestnut Hill, MA 02467, USA; Brigham and Women's Hospital, Department of Neurology, Boston, MA, USA.
  • Root JC; Memorial Sloan Kettering Cancer Center, Department of Psychiatry and Behavioral Sciences, New York, NY, USA.
  • Tuescher O; University Medical Center Freiburg, Department of Neurology, Freiburg im Breisgau, Germany; University Medical Centre Mainz, Department of Psychiatry and Psychotherapy, Mainz, Germany.
  • Fischer DB; Functional Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Department of Psychiatry, 824 Boylston Street, Chestnut Hill, MA 02467, USA.
  • Butler T; Langone Medical Center, New York University School of Medicine, New York, NY, USA.
  • Vago DR; Functional Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Department of Psychiatry, 824 Boylston Street, Chestnut Hill, MA 02467, USA.
  • Isenberg N; Neuroscience Institute, Virginia Mason Medical Center, Seattle, WA, USA.
  • Epstein J; Functional Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Department of Psychiatry, 824 Boylston Street, Chestnut Hill, MA 02467, USA.
  • Landa Y; Weill Cornell Medical Center, Department of Psychiatry, New York, NY, USA.
  • Smith TE; New York State Psychiatric Institute, Columbia University, New York, NY, USA.
  • Savitz AJ; Weill Cornell Medical Center, Department of Psychiatry, New York, NY, USA.
  • Silbersweig DA; Functional Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Department of Psychiatry, 824 Boylston Street, Chestnut Hill, MA 02467, USA; Brigham and Women's Hospital, Department of Neurology, Boston, MA, USA.
  • Stern E; Functional Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Department of Psychiatry, 824 Boylston Street, Chestnut Hill, MA 02467, USA; Brigham and Women's Hospital, Department of Radiology, Harvard Medical School, Boston, MA, USA. Electronic address: estern3@partners.
Psychiatry Res ; 233(3): 352-66, 2015 Sep 30.
Article en En | MEDLINE | ID: mdl-26208746
Persecutory delusions are a clinically important symptom in schizophrenia associated with social avoidance and increased violence. Few studies have investigated the neurobiology of persecutory delusions, which is a prerequisite for developing novel treatments. The aim of this two-paradigm functional magnetic resonance imaging (fMRI) study is to characterize social "real world" and linguistic threat brain activations linked to persecutory delusions in schizophrenia (n=26) using instructed-fear/safety and emotional word paradigms. Instructed-fear/safety activations correlated to persecutory delusion severity demonstrated significant increased lateral orbitofrontal cortex and visual association cortex activations for the instructed-fear vs. safety and instructed-fear vs. baseline contrasts; decreased lateral orbitofrontal cortex and ventral occipital-temporal cortex activations were observed for the instructed-safety stimuli vs. baseline contrast. The salience network also showed divergent fear and safety cued activations correlated to persecutory delusions. Emotional word paradigm analyses showed positive correlations between persecutory delusion severity and left-lateralized linguistic and hippocampal-parahippocampal activations for the threat vs. neutral word contrast. Visual word form area activations correlated positively with persecutory delusions for both threat and neutral word vs. baseline contrasts. This study links persecutory delusions to enhanced neural processing of threatening stimuli and decreased processing of safety cues, and helps elucidate systems-level activations associated with persecutory delusions in schizophrenia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Desempeño Psicomotor / Esquizofrenia / Imagen por Resonancia Magnética / Deluciones / Miedo / Red Nerviosa Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Psychiatry Res Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Desempeño Psicomotor / Esquizofrenia / Imagen por Resonancia Magnética / Deluciones / Miedo / Red Nerviosa Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: Psychiatry Res Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Irlanda