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Emergence of hepatitis C virus NS5A L31V plus Y93H variant upon treatment failure of daclatasvir and asunaprevir is relatively resistant to ledipasvir and NS5B polymerase nucleotide inhibitor GS-558093 in human hepatocyte chimeric mice.
Kai, Yugo; Hikita, Hayato; Tatsumi, Tomohide; Nakabori, Tasuku; Saito, Yoshinobu; Morishita, Naoki; Tanaka, Satoshi; Nawa, Takatoshi; Oze, Tsugiko; Sakamori, Ryotaro; Yakushijin, Takayuki; Hiramatsu, Naoki; Suemizu, Hiroshi; Takehara, Tetsuo.
Afiliación
  • Kai Y; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Hikita H; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Tatsumi T; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Nakabori T; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Saito Y; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Morishita N; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Tanaka S; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Nawa T; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Oze T; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Sakamori R; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Yakushijin T; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Hiramatsu N; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.
  • Suemizu H; Department of Laboratory Animal Research, Central Institute for Experimental Animals, Kawasaki, Japan.
  • Takehara T; Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. takehara@gh.med.osaka-u.ac.jp.
J Gastroenterol ; 50(11): 1145-51, 2015 Nov.
Article en En | MEDLINE | ID: mdl-26208695
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hepacivirus / Hepatitis C Crónica / Farmacorresistencia Viral Múltiple / Hepatitis Viral Animal Límite: Animals / Female / Humans / Male / Middle aged Idioma: En Revista: J Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hepacivirus / Hepatitis C Crónica / Farmacorresistencia Viral Múltiple / Hepatitis Viral Animal Límite: Animals / Female / Humans / Male / Middle aged Idioma: En Revista: J Gastroenterol Asunto de la revista: GASTROENTEROLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Japón