Your browser doesn't support javascript.
loading
Duration of fasting but not diurnal variation affects the response to glucagon in healthy cats.
Gilor, C; Glock, R; Gilor, S.
Afiliación
  • Gilor C; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA. Electronic address: gilor.1@osu.edu.
  • Glock R; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
  • Gilor S; Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
Domest Anim Endocrinol ; 53: 103-7, 2015 Oct.
Article en En | MEDLINE | ID: mdl-26201763
The role of glucagon disturbances in diabetes is increasingly recognized. Glucagon stimulation tests (GSTs) have been described in cats previously, but information is lacking on the response of cats to glucagon under specific conditions. The aim of this study was to assess a novel protocol for GST using human-recombinant glucagon and the effect of diurnal variation and duration of fasting using this protocol in healthy cats. All intravenous doses resulted in occasional vomiting and nausea, and eventually, a 20-µg/kg intramuscular dose was chosen. Five healthy cats were then used in a repeated-measures study. Cats were free-fed regularly at 7:30 AM and 5:30 PM for 30 min. In each cat, GST was performed at 7 PM after a 25-h fast (PM25), at 9 AM after a 25-h fast (AM25), and at 9 AM after a 15-h fast (AM15). Glucose and insulin concentrations were measured at -15, 0, 15, 25, 35, 45, and 60 min after stimulation. Baseline and peak concentrations were compared using the Friedman test. Baseline glucose and insulin did not differ significantly between treatment groups. Peak glucose concentrations occurred at 15 min and were significantly higher (P = 0.0085) at AM15 (mean ± standard deviation = 185.2 ± 43.0 mg/dL) vs AM25 (144.4 ± 10.5 mg/dL) and PM25 (128.0 ± 18.4 mg/dL). Similarly, peak insulin concentrations occurred at 15 min and were significantly higher (P = 0.04) at AM15 (1,911 ± 1,153 pg/mL) vs AM25 (739 ± 52 pg/mL) or PM25 (549 ± 366 pg/mL). In conclusion, prolonged fasting significantly blunted the glycemic response to glucagon compared with shorter fasting, but diurnal variation had no significant effect on glucose or insulin responses.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Glucagón / Gatos / Ritmo Circadiano / Privación de Alimentos Tipo de estudio: Guideline Límite: Animals Idioma: En Revista: Domest Anim Endocrinol Asunto de la revista: ENDOCRINOLOGIA / MEDICINA VETERINARIA Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glucemia / Glucagón / Gatos / Ritmo Circadiano / Privación de Alimentos Tipo de estudio: Guideline Límite: Animals Idioma: En Revista: Domest Anim Endocrinol Asunto de la revista: ENDOCRINOLOGIA / MEDICINA VETERINARIA Año: 2015 Tipo del documento: Article Pais de publicación: Estados Unidos