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Immature dendritic cell exosomes suppress experimental autoimmune myasthenia gravis.
Bu, Ning; Wu, Hai-Qin; Zhang, Gui-Lian; Zhan, Shu-Qin; Zhang, Ru; Fan, Qing-Yu; Li, Yan-Ling; Zhai, Yue-Fan; Ren, Hong-Wei.
Afiliación
  • Bu N; Department of Neurology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China. Electronic address: ningbuxa@163.com.
  • Wu HQ; Department of Neurology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China.
  • Zhang GL; Department of Neurology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China.
  • Zhan SQ; Department of Neurology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China.
  • Zhang R; Department of Neurology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China.
  • Fan QY; Department of Neurology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China.
  • Li YL; Department of Neurology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China.
  • Zhai YF; Department of Neurology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China.
  • Ren HW; Department of Neurology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, PR China.
J Neuroimmunol ; 285: 71-5, 2015 Aug 15.
Article en En | MEDLINE | ID: mdl-26198922
Immature dendritic cell-derived exosomes (iMDEX) display a certain degree of immunosuppressive activity in autoimmune diseases. However, the role of iMDEX in experimental autoimmune myasthenia gravis (EAMG) is still unclear. Therefore, we tested the effects of mouse bone marrow (BM)-derived iMDEX on tolerance induction in a mouse model of EAMG. In this study, we found that the CELLine culture system produced more exosomes, the morphology and phenotype of these exosomes were found to be identical when compared with traditional cell culture. And, iMDEX(1000) ameliorated the progression of EAMG by reducing AChR-reactive lymphocyte proliferation, AChR antibody levels and pro-inflammatory cytokine levels.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Dendríticas / Miastenia Gravis Autoinmune Experimental / Exosomas Límite: Animals Idioma: En Revista: J Neuroimmunol Año: 2015 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Dendríticas / Miastenia Gravis Autoinmune Experimental / Exosomas Límite: Animals Idioma: En Revista: J Neuroimmunol Año: 2015 Tipo del documento: Article Pais de publicación: Países Bajos