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Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor.
Karpov, Alexei S; Amiri, Payman; Bellamacina, Cornelia; Bellance, Marie-Helene; Breitenstein, Werner; Daniel, Dylan; Denay, Regis; Fabbro, Doriano; Fernandez, Cesar; Galuba, Inga; Guerro-Lagasse, Stephanie; Gutmann, Sascha; Hinh, Linda; Jahnke, Wolfgang; Klopp, Julia; Lai, Albert; Lindvall, Mika K; Ma, Sylvia; Möbitz, Henrik; Pecchi, Sabina; Rummel, Gabriele; Shoemaker, Kevin; Trappe, Joerg; Voliva, Charles; Cowan-Jacob, Sandra W; Marzinzik, Andreas L.
Afiliación
  • Karpov AS; Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Amiri P; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Bellamacina C; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Bellance MH; Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Breitenstein W; Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Daniel D; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Denay R; Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Fabbro D; Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Fernandez C; Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Galuba I; Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Guerro-Lagasse S; Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Gutmann S; Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Hinh L; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Jahnke W; Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Klopp J; Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Lai A; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Lindvall MK; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Ma S; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Möbitz H; Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Pecchi S; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Rummel G; Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Shoemaker K; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Trappe J; Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Voliva C; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
  • Cowan-Jacob SW; Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
  • Marzinzik AL; Novartis Institutes for BioMedical Research , Novartis Campus, CH-4056 Basel, Switzerland.
ACS Med Chem Lett ; 6(7): 776-81, 2015 Jul 09.
Article en En | MEDLINE | ID: mdl-26191365
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Med Chem Lett Año: 2015 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Med Chem Lett Año: 2015 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos