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Elucidating an Affective Pain Circuit that Creates a Threat Memory.
Han, Sung; Soleiman, Matthew T; Soden, Marta E; Zweifel, Larry S; Palmiter, Richard D.
Afiliación
  • Han S; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.
  • Soleiman MT; Graduate Program in Neuroscience, University of Washington, Seattle, WA 98195, USA.
  • Soden ME; Departments of Psychiatry and Pharmacology, University of Washington, Seattle, WA 98195, USA.
  • Zweifel LS; Departments of Psychiatry and Pharmacology, University of Washington, Seattle, WA 98195, USA.
  • Palmiter RD; Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA; Graduate Program in Neuroscience, University of Washington, Seattle, WA 98195, USA. Electronic address: palmiter@uw.edu.
Cell ; 162(2): 363-374, 2015 Jul 16.
Article en En | MEDLINE | ID: mdl-26186190
Animals learn to avoid harmful situations by associating a neutral stimulus with a painful one, resulting in a stable threat memory. In mammals, this form of learning requires the amygdala. Although pain is the main driver of aversive learning, the mechanism that transmits pain signals to the amygdala is not well resolved. Here, we show that neurons expressing calcitonin gene-related peptide (CGRP) in the parabrachial nucleus are critical for relaying pain signals to the central nucleus of amygdala and that this pathway may transduce the affective motivational aspects of pain. Genetic silencing of CGRP neurons blocks pain responses and memory formation, whereas their optogenetic stimulation produces defensive responses and a threat memory. The pain-recipient neurons in the central amygdala expressing CGRP receptors are also critical for establishing a threat memory. The identification of the neural circuit conveying affective pain signals may be pertinent for treating pain conditions with psychiatric comorbidities.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Amígdala del Cerebelo / Vías Nerviosas / Neuronas Límite: Animals Idioma: En Revista: Cell Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dolor / Amígdala del Cerebelo / Vías Nerviosas / Neuronas Límite: Animals Idioma: En Revista: Cell Año: 2015 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos