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Anxiety is related to indices of cortical maturation in typically developing children and adolescents.
Newman, Erik; Thompson, Wesley K; Bartsch, Hauke; Hagler, Donald J; Chen, Chi-Hua; Brown, Timothy T; Kuperman, Joshua M; McCabe, Connor; Chung, Yoonho; Libiger, Ondrej; Akshoomoff, Natacha; Bloss, Cinnamon S; Casey, B J; Chang, Linda; Ernst, Thomas M; Frazier, Jean A; Gruen, Jeffrey R; Kennedy, David N; Murray, Sarah S; Sowell, Elizabeth R; Schork, Nicholas; Kenet, Tal; Kaufmann, Walter E; Mostofsky, Stewart; Amaral, David G; Dale, Anders M; Jernigan, Terry L.
Afiliación
  • Newman E; Center for Human Development, University of California, San Diego, 9500 Gilman Drive, MC 0115, La Jolla, CA, 92093, USA. enewman@ucsd.edu.
  • Thompson WK; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA. enewman@ucsd.edu.
  • Bartsch H; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
  • Hagler DJ; Stein Institute for Research on Aging, University of California, San Diego, La Jolla, CA, USA.
  • Chen CH; Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, CA, USA.
  • Brown TT; Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, CA, USA.
  • Kuperman JM; Department of Radiology, University of California, San Diego, La Jolla, CA, USA.
  • McCabe C; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
  • Chung Y; Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, CA, USA.
  • Libiger O; Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, CA, USA.
  • Akshoomoff N; Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA.
  • Bloss CS; Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, CA, USA.
  • Casey BJ; Department of Radiology, University of California, San Diego, La Jolla, CA, USA.
  • Chang L; Center for Human Development, University of California, San Diego, 9500 Gilman Drive, MC 0115, La Jolla, CA, 92093, USA.
  • Ernst TM; Department of Psychology, University of Washington, Seattle, WA, USA.
  • Frazier JA; Center for Human Development, University of California, San Diego, 9500 Gilman Drive, MC 0115, La Jolla, CA, 92093, USA.
  • Gruen JR; Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, CA, USA.
  • Kennedy DN; Department of Psychology, Yale University, New Haven, CT, USA.
  • Murray SS; Scripps Genomic Medicine, Scripps Translational Science Institute and Scripps Health, La Jolla, CA, USA.
  • Sowell ER; Center for Human Development, University of California, San Diego, 9500 Gilman Drive, MC 0115, La Jolla, CA, 92093, USA.
  • Schork N; Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA.
  • Kenet T; Scripps Genomic Medicine, Scripps Translational Science Institute and Scripps Health, La Jolla, CA, USA.
  • Kaufmann WE; Sackler Institute for Developmental Psychobiology, Weil Cornell Medical College, New York, NY, USA.
  • Mostofsky S; Department of Medicine, University of Hawaii and Queen's Medical Center, Honolulu, HI, USA.
  • Amaral DG; Department of Medicine, University of Hawaii and Queen's Medical Center, Honolulu, HI, USA.
  • Dale AM; Department of Psychiatry, University of Massachusetts Medical School, Boston, MA, USA.
  • Jernigan TL; Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA.
Brain Struct Funct ; 221(6): 3013-25, 2016 07.
Article en En | MEDLINE | ID: mdl-26183468
Anxiety is a risk factor for many adverse neuropsychiatric and socioeconomic outcomes, and has been linked to functional and structural changes in the ventromedial prefrontal cortex (VMPFC). However, the nature of these differences, as well as how they develop in children and adolescents, remains poorly understood. More effective interventions to minimize the negative consequences of anxiety require better understanding of its neurobiology in children. Recent research suggests that structural imaging studies may benefit from clearly delineating between cortical surface area and thickness when examining these associations, as these distinct cortical phenotypes are influenced by different cellular mechanisms and genetic factors. The present study examined relationships between cortical surface area and thickness of the VMPFC and a self-report measure of anxiety (SCARED-R) in 287 youths aged 7-20 years from the Pediatric Imaging, Neurocognition, and Genetics (PING) study. Age and gender interactions were examined for significant associations in order to test for developmental differences. Cortical surface area and thickness were also examined simultaneously to determine whether they contribute independently to the prediction of anxiety. Anxiety was negatively associated with relative cortical surface area of the VMPFC as well as with global cortical thickness, but these associations diminished with age. The two cortical phenotypes contributed additively to the prediction of anxiety. These findings suggest that higher anxiety in children may be characterized by both delayed expansion of the VMPFC and an altered trajectory of global cortical thinning. Further longitudinal studies will be needed to confirm these findings.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ansiedad / Trastornos de Ansiedad / Corteza Prefrontal Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Brain Struct Funct Asunto de la revista: CEREBRO Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ansiedad / Trastornos de Ansiedad / Corteza Prefrontal Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Revista: Brain Struct Funct Asunto de la revista: CEREBRO Año: 2016 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania