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Feasibility and safety of enoxaparin whole milligram dosing in premature and term neonates.
Goldsmith, R; Chan, A K; Paes, B A; Bhatt, M D.
Afiliación
  • Goldsmith R; Division of Pediatric Hematology/Oncology, McMaster Children's Hospital, McMaster University, Hamilton, ON, Canada.
  • Chan AK; Division of Pediatric Hematology/Oncology, McMaster Children's Hospital, McMaster University, Hamilton, ON, Canada.
  • Paes BA; Division of Neonatology, McMaster Children's Hospital, McMaster University, Hamilton, ON, Canada.
  • Bhatt MD; Division of Pediatric Hematology/Oncology, McMaster Children's Hospital, McMaster University, Hamilton, ON, Canada.
J Perinatol ; 35(10): 852-4, 2015 Oct.
Article en En | MEDLINE | ID: mdl-26181722
OBJECTIVE: The objective of our study was to determine the feasibility and safety of enoxaparin whole milligram dosing in premature and term neonates, and to assess response to treatment. STUDY DESIGN: Retrospective study of neonates with thrombosis treated between January 2008 and December 2014. RESULT: Nineteen premature and 21 term neonates were treated with whole milligram doses of enoxaparin. The mean starting and therapeutic enoxaparin doses were 1.72±0.17 and 1.86±0.17 mg kg(-1), respectively. Twenty-five (64%) reached therapeutic antifactor Xa (anti-Xa) levels with the starting dose, whereas 14 (36%) required dose adjustments. One neonate reached a supratherapeutic anti-Xa level (>1.0 IU ml(-1)) in the loading phase. No bleeding episodes occurred. The mean treatment duration was 12 weeks. Among 34 (85%) evaluable patients, 23 (68%) had a complete response, 9 (26%) partial and 2 (6%) had a stable thrombotic state. CONCLUSION: Whole milligram dosing of enoxaparin for thrombosis is feasible, safe and effective in premature and term neonates.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombosis / Enoxaparina / Anticoagulantes Tipo de estudio: Observational_studies Límite: Female / Humans / Male / Newborn Idioma: En Revista: J Perinatol Asunto de la revista: PERINATOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trombosis / Enoxaparina / Anticoagulantes Tipo de estudio: Observational_studies Límite: Female / Humans / Male / Newborn Idioma: En Revista: J Perinatol Asunto de la revista: PERINATOLOGIA Año: 2015 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos