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Multicenter Evaluation of the Molecular Line Probe Assay for Multidrug Resistant Mycobacterium Tuberculosis Detection in China.
Li, Qiang; Dong, Hai Yan; Pang, Yu; Xia, Hui; Ou, Xi Chao; Zhang, Zhi Ying; Li, Jun Chen; Zhang, Jian Kang; Huan, Shi Tong; Chin, Daniel P; Kam, Kai Man; Zhao, Yan Lin.
Afiliación
  • Li Q; National Tuberculosis Reference Laboratory, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
  • Dong HY; PATH Beijing Office, Beijing 100600, China.
  • Pang Y; National Tuberculosis Reference Laboratory, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
  • Xia H; National Tuberculosis Reference Laboratory, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
  • Ou XC; National Tuberculosis Reference Laboratory, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
  • Zhang ZY; PATH Beijing Office, Beijing 100600, China.
  • Li JC; PATH Beijing Office, Beijing 100600, China.
  • Zhang JK; PATH Beijing Office, Beijing 100600, China.
  • Huan ST; Gates Foundation Beijing Office, Beijing 100600, China.
  • Chin DP; Gates Foundation Beijing Office, Beijing 100600, China.
  • Kam KM; Chinese University of HongKong, HongKong 649490, China.
  • Zhao YL; National Tuberculosis Reference Laboratory, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Biomed Environ Sci ; 28(6): 464-7, 2015 Jun.
Article en En | MEDLINE | ID: mdl-26177909
In order to evaluate the performance of a molecular Hain line probe assay (Hain LPA) for rapid detection of rifampicin and isoniazid resistance of Mycobacterium tuberculosis in China, 1612 smear positive patients were consecutively enrolled in this study. Smear positive sputum specimens were collected for Hain LPA and conventional drug susceptibility testing (DST). The sensitivity and specificity of Hain LPA were analyzed by using conventional DST as golden reference. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for rifampicin resistance detection were 88.33%, 97.66%, 81.54%, and 98.62%, respectively. The sensitivity, specificity, PPV and NPV for isoniazid resistance detection were 80.25%, 98.07%, 87.25%, and 96.78%, respectively. These findings suggested that Hain LPA can be an effective method worthy of broader use in China.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tuberculosis Resistente a Múltiples Medicamentos / Técnicas de Genotipaje / Mycobacterium tuberculosis Tipo de estudio: Clinical_trials / Diagnostic_studies / Evaluation_studies / Prognostic_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Biomed Environ Sci Asunto de la revista: SAUDE AMBIENTAL Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tuberculosis Resistente a Múltiples Medicamentos / Técnicas de Genotipaje / Mycobacterium tuberculosis Tipo de estudio: Clinical_trials / Diagnostic_studies / Evaluation_studies / Prognostic_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Biomed Environ Sci Asunto de la revista: SAUDE AMBIENTAL Año: 2015 Tipo del documento: Article País de afiliación: China Pais de publicación: China