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In vitro evaluation of the antioxidant and antimicrobial activity of DIMBOA [2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one].
Glensk, Michal; Gajda, Beata; Franiczek, Roman; Krzyzanowska, Barbara; Biskup, Izabela; Wlodarczyk, Maciej.
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  • Glensk M; a Department of Pharmacognosy , Wroclaw Medical University , Borowska 211 A, 50-556 Wroclaw , Poland.
  • Gajda B; a Department of Pharmacognosy , Wroclaw Medical University , Borowska 211 A, 50-556 Wroclaw , Poland.
  • Franiczek R; b Department of Microbiology , Wroclaw Medical University , Chalubinskiego 4, 50-368 Wroclaw , Poland.
  • Krzyzanowska B; b Department of Microbiology , Wroclaw Medical University , Chalubinskiego 4, 50-368 Wroclaw , Poland.
  • Biskup I; a Department of Pharmacognosy , Wroclaw Medical University , Borowska 211 A, 50-556 Wroclaw , Poland.
  • Wlodarczyk M; a Department of Pharmacognosy , Wroclaw Medical University , Borowska 211 A, 50-556 Wroclaw , Poland.
Nat Prod Res ; 30(11): 1305-8, 2016 Jun.
Article en En | MEDLINE | ID: mdl-26166773
The aim of this study was to evaluate the in vitro antioxidant and antimicrobial properties of the natural cyclic hydroxamic acid: 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one (DIMBOA). Antioxidant activity of the isolated DIMBOA was examined using DPPH, FRAP and ABTS tests. It was found that DIMBOA exhibits a potent free-radical scavenging activity and a weaker iron (III) ions reducing activity. Antimicrobial activity against selected G(+), G(-) bacterial strains and against yeasts-like reference strains of fungi was investigated using disk-diffusion method. It has been shown that DIMBOA possess growth inhibitory properties against many strains of studied bacteria and fungi, such as Staphylococcus aureus, Escherichia coli as well as against Saccharomyces cerevisiae.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Benzoxazinas / Antiinfecciosos / Antioxidantes Límite: Animals Idioma: En Revista: Nat Prod Res Año: 2016 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido
Texto completo
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Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Benzoxazinas / Antiinfecciosos / Antioxidantes Límite: Animals Idioma: En Revista: Nat Prod Res Año: 2016 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Reino Unido