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Audiologic profile of OSAS and simple snoring patients: the effect of chronic nocturnal intermittent hypoxia on auditory function.
Martines, Francesco; Ballacchino, Antonella; Sireci, Federico; Mucia, Marianna; La Mattina, Eleonora; Rizzo, Serena; Salvago, Pietro.
Afiliación
  • Martines F; Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche, (BioNeC), Sezione di Otorinolaringoiatria, Università degli Studi di Palermo, Via del Vespro, 129-90127, Palermo, Italy.
  • Ballacchino A; Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi (Di.Bi.Me.F.), Sezione di Audiologia, Università degli Studi di Palermo, Via del Vespro, 129-90127, Palermo, Italy.
  • Sireci F; Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche, (BioNeC), Sezione di Otorinolaringoiatria, Università degli Studi di Palermo, Via del Vespro, 129-90127, Palermo, Italy.
  • Mucia M; Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche, (BioNeC), Sezione di Otorinolaringoiatria, Università degli Studi di Palermo, Via del Vespro, 129-90127, Palermo, Italy.
  • La Mattina E; Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi (Di.Bi.Me.F.), Sezione di Audiologia, Università degli Studi di Palermo, Via del Vespro, 129-90127, Palermo, Italy.
  • Rizzo S; Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi (Di.Bi.Me.F.), Sezione di Audiologia, Università degli Studi di Palermo, Via del Vespro, 129-90127, Palermo, Italy.
  • Salvago P; Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi (Di.Bi.Me.F.), Sezione di Audiologia, Università degli Studi di Palermo, Via del Vespro, 129-90127, Palermo, Italy.
Eur Arch Otorhinolaryngol ; 273(6): 1419-24, 2016 Jun.
Article en En | MEDLINE | ID: mdl-26164293
The objective of this work was to study the effect of nocturnal intermittent hypoxia on auditory function of simple snoring patients and subjects affected by OSAS; we compared the audiologic profile with the severity of OSAS to detect early signs of cochlear damage. One hundred-sixty patients underwent overnight polysomnography, micro-otoscopy, multi-frequency audiometry, acufenometry, TEOAE recording and d-ROMs test. All subjects were divided in four groups, based on presence/absence of AHI (simple snoring without OSAS, mild OSAS, moderate OSAS, severe OSAS). Sixty (37.5 %) patients were not affected by OSAS, 58 (36.25 %) presented a mild OSAS, 18 (11.25 %) a moderate OSAS and 24 (15 %) a severe OSAS; the 57.14 % of moderate to severe OSAS suffered from tinnitus with respect to the 31.03 % of mild OSAS (P = 0.024). A higher percentage (41.66 %) of hearing loss was found among individuals with moderate to severe degree of OSAS (P < 0.0001). All groups were characterized by a mean hearing threshold <25 dB HL for 0.25-3 kHz frequencies and a progressive decrease in hearing sensitivity, particularly for 6-16 kHz frequencies (P < 0.05). The analysis of otoacoustic emissions SNR mean values evidenced a significant difference between simple snoring and severe OSAS individuals for 3 and 4 kHz frequencies (P < 0.05). d-ROM levels resulted higher in patients with severe OSAS with respect to simple snoring subjects (P = 0.004). Our data underline the key role of chronic nocturnal intermittent hypoxia in the development of an early cochlear damage and a more marked high-frequency hearing loss in case of severe OSAS (P < 0.05).
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ronquido / Acúfeno / Apnea Obstructiva del Sueño / Pérdida Auditiva Tipo de estudio: Etiology_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Eur Arch Otorhinolaryngol Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ronquido / Acúfeno / Apnea Obstructiva del Sueño / Pérdida Auditiva Tipo de estudio: Etiology_studies Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Eur Arch Otorhinolaryngol Asunto de la revista: OTORRINOLARINGOLOGIA Año: 2016 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Alemania